Prognostic value of lymphovascular invasion in stage II colorectal cancer patients with an inadequate examination of lymph nodes

Table 2 Occurrence of LVI in 265 stage II CRC patients. The incidence of LVI in stage II CRC patients is listed in Table 2 according to clinicopathologic characteristics. The LVI status was significantly associated with pT stage, degree of differentiation, tumor stage, serum CEA and CA19-9 levels, perineural invasion, tumor budding, and KRAS status. No significance existed in sex, age, tumor size, tumor site, and ELNs

Parameters	LVI (+)	LVI (−)	P value	LVI (+) rate (%)
	n	n
Sex			0.563
Female	43	65		43/108 (39.8%)
Male	57	100		57/157 (36.3%)
Age (years)			0.102
≤65	54	72		54/126 (42.9%)
>65	46	93		46/139 (33.1%)
Tumor site			0.276
Colon	59	86		59/145 (40.7%)
Rectum	41	79		41/120 (34.2%)
T-stage			< 0.001
T3	33	111		33/144 (22.9%)
T4a	31	34		31/65 (47.7%)
T4b	36	20		36/56 (64.3%)
Tumor size (cm)			0.186
≤4	48	93		48/141 (34.0%)
>4	52	72		52/124 (41.9%)
Differentiation degree			< 0.001
Well	38	97		38/135 (28.1%)
Moderate	52	66		52/118 (44.1%)
Poor	10	2		10/12 (83.3%)
CEA			< 0.001
≤5ng/ml	28	133		28/161 (17.4%)
>5ng/ml	72	32		72/104 (69.2%)
CA19-9			< 0.001
≤37U/ml	61	151		61/212 (28.8%)
>37U/ml	39	14		39/53 (73.6%)
Retrieved LN			0.062
<12	48	60		48/108 (44.4%)
≥12	52	105		52/157 (33.1%)
Treatment			< 0.001
ACT	78	43		78/101 (64.5%)
SA	22	122		22/144 (15.3%)
II			0.023
IIA	37	76		37/113 (32.7%)
IIB	34	44		34/78 (43.6%)
IIC	39	35		39/74 (52.7%)
KRAS status			< 0.001
Wild type	39	121		39/160 (24.4%)
Mutant type	61	44		61/105 (58.1%)
PNI			< 0.001
Negative	66	141		66/207 (31.9%)
Positive	34	24		34/58 (58.6%)
TB			< 0.001
Low	59	136		59/195 (30.3%)
High	41	29		41/70 (58.6%)

CRC Colorectal cancer; LN Lymph nodes; LVI Lymphovascular invasion; PNI Perineural invasion; TB Tumor budding
Table 2. Occurrence of LVI in 265 stage II CRC patients

ISSN: 1477-7819