Fig. 4

Representative images of gross and histological findings in IHCC tumors. a–c CT images showed the presence of a 5.5 cm, low density mass in the S3 segment of the liver in all phases. d The resected specimen showed the presence of a nodular tumor in the S3 segment of the liver. This tumor was consistent with the mass-forming type. e Histologic findings (× 100 magnification) revealed that the tumor consisted of duct-forming, abundant fibrotic stroma. The cancer cells had a clear cytoplasm. f SSTR2 expression can be seen in the cell membrane of IHCC tumor cells (× 100 magnification). g IHCC cancer cells were negative for Bcl2 (× 100 magnification). IHCC: intrahepatic cholangiocarcinoma, CT: computed tomography. SSTR2: somatostatin receptor 2, Bcl2: b-cell leukemia/lymphoma 2