Table 1 Characteristics of the included studies
From: Left-side vs. right-side hepatectomy for hilar cholangiocarcinoma: a meta-analysis
Study | Study design | Location/period | Follow-up (monthsa) | No. of patients (male, %) | Age, (yearsa) | No. of stage I/II/III/IV | No. of biliary drainage (EBD/PBD) | No. of PVE | Caudate lobectomy, % | Main findings |
|---|---|---|---|---|---|---|---|---|---|---|
Bednarsch et al. [28] | Cohort study | Germany/ 2011–2016 | 28 (0–90) | LH: 36 (63.9) | 67 ± 9 | 1/0/23/12 | 35 (27/8) | 0 | 100 | 3- and 5-year OS rate, LH = 62%,30% vs. RH = 51%,46%; R0, LH = 69.4% vs. RH = 75.6% |
RH: 45 (68.9) | 67 ± 11 | 2/6/23/14 | 46 (35/11) | 37 | 100 | |||||
Govil et al. [19] | Cohort study | India/ 2009–2015 | 14 (3–64) | LH: 23 (NR) | 58 (20–74) | 0/0/28/8 | 8 (0/8) | 0 | NR | 2-year OS rate, LH = 39%vs. RH = 44%, R0, NR |
RH: 13(NR) | 6 (0/6) | 0 | NR | |||||||
Hong et al. [29] | Cohort study | Korea/ 2000–2018 | NR | LH: 82 (68.3) | 63.46 ± 10.38 | 5/6/43/28 | 60 | 2 | 100 | 1-, 3-, and 5-year OS rate, LH = 87.3%, 38.2%, 24.7% vs. RH = 77.2%, 41.4%, 26.8%; R0, LH = 75.6% vs. RH = 72.8% |
RH: 114 (66.7) | 63.64 ± 8.72 | 4/13/75/22 | 93 | 45 | 100 | |||||
Jo et al. [15] | Cohort study | Korea/ 2010–2017 | 19 (1–97) | LH: 24 (62.5) | 71 (53–83) | IV: 7 | 22(14/8) | 0 | 100 | 1-, 3-, and 5-year OS rate, LH = 82.6%, 50.6%, 40.5% vs. RH = 69.3%, 48.5%, 37.7%; R0, LH = 75% vs. RH = 75.8% |
RH: 33 (66.6) | 66 (42–79) | IV: 12 | 29(20/9) | 6 | 100 | |||||
Lee et al. [30] | Cohort study | Korea/ 1995–2012 | NR | LH: 35 (57.1) | 61.0 ± 8.1 | IIIb:35 | 23 | 0 | 94.3 | 1-, 3-, and 5-year OS rate, LH = 80%, 47%, 35% vs. RH = 85%, 47%, 33%; R0, LH = 85.7% vs. RH = 82.5% |
RH: 103 (66) | 62.1 ± 9.2 | IIIa: 103 | 71 | 24 | 86.4 | |||||
Otto et al. [31] | Cohort study | Germany/ 1998–2011 | NR | LH: 68 (75) | 64 (39–83) | 0/0/35/33 | NR | 0 | 100 | 1- and 5-year OS rate, LH = 72%, 22% vs. RH = 73%, 29%; R0, LH = 72.1% vs. RH = 82.4% |
RH: 68 (66.2) | 62 (44–82) | 1/0/37/30 | NR | 4 | 100 | |||||
Ratti et al. [32] | Cohort study | Italy/ 2004–2014 | 23(3–98) | LH: 44 (68.1) | 59 (36–79) | 1/17/13/13 | 23(6/16)b | 0 | 97.7 | 3- and 5-year OS rate, LH = 49.5%, 35.3% vs. RH = 53.2%, 42.8%; R0, LH = 61.4% vs. RH = 75.4% |
RH: 61 (50.8) | 62 (41–82) | 1/20/15/25 | 39(9/22)b | 29 | 93.4 | |||||
Shimizu et al. [11] | Cohort study | Japan/ 1984–2008 | NR | LH: 88 (69.3) | 67.0 ± 8.9 | IIIb: 88 | NR | 5 | 100 | 1-, 3-, and 5-year OS rate, NR; R0, LH = 63.6% vs. RH = 69.1% |
RH: 84 (56) | 67.1 ± 8.0 | IIIa +V: 84 | NR | 32 | 100 | |||||
Sugiura et al. [33] | Cohort study | Japan/ 2002–2013 | NR | LH: 12 (91.7) | 65 (58–84) | 2/10/0/0 | NR | 0 | 100 | 3- and 5-year OS rate, LH = 66.7%, 41.7% vs. RH = 70.8%, 49%; R0, NR |
RH: 24 (75) | 68 (37–81) | 8/16/0/0 | NR | 24 | 100 | |||||
Konstadoulakis et al. [34] | Cohort study | USA/ 1988–2006 | 38 ± 30.4 | LH: 29 | NR | NR | NR | 0 | 77.6 | 1-, 3-, and 5-year OS rate, LH = 66.7%, 33.3%, 21.7% vs. RH = 85%, 63.2%, 50%; R0, NR |
RH: 20 | NR | NR | NR | 1 | ||||||
Yamanaka et al. [35] | Cohort study | Japan/ 1980–1998 | NR | LH: 11 (54.5) | 60 ± 11 | NR | NR | NR | 100 | OS, HR, 0.53 95% CI, 0.02–15.24; R0, NR |
RH: 14 (64.3) | 55 ± 10 | NR | NR | NR | 93 |