Fig. 4

MiR-197-3p is a target of hsa_circ_0025202. a qRT-PCR analysis of miR-197-3p expression in BC tissues and matched non-tumor tissues. b qRT-PCR analysis of miR-197-3p expression in normal MCF-10A cells, BC cell lines (T47D and MCF7) and TAM-resistant BC cell lines (T47D/TAM and MCF7/TAM). c The correlation between hsa_circ_0025202 level and miR-197-3p expression in BC tissues using the Pearson correlation analysis. d Sequence alignment of miR-197-3p with the putative binding sites in the wild-type regions of hsa_circ_0025202. e Luciferase activities detection in 293 T cells co-transfected with the reporter plasmids and indicated miRNAs using the dual-luciferase reporter assay. f qRT-PCR analysis of hsa_circ_0025202 and miR-197-3p levels in T47D and MCF7 cells after RIP assay. **P < 0.01, ***P < 0.001, ^#P < 0.05, ^###P < 0.001