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Table 2 Univariate and multivariate logistic regression for analysing the demographic and related clinical characteristics for developing distant metastases in patients diagnosed with colorectal cancer (diagnosed 2010–2016)

From: Nomogram based on homogeneous and heterogeneous associated factors for predicting distant metastases in patients with colorectal cancer

Subject characteristics Univariate Multivariate
OR (95% CI) P value OR (95% CI) P value
Age(years)
 ≤ 50 1 (reference) 1.00 1 (reference) 1.00
 51–60 0.95 (0.92–0.99) 0.012 0.94 (0.90–0.98) 0.007
 61–70 0.92 (0.88–0.95) < 0.001 0.93 (0.89–0.97) 0.001
 71–80 0.81 (0.78–0.85) < 0.001 0.86 (0.82–0.90) < 0.001
 81–90 0.80 (0.77–0.83) < 0.001 0.76 (0.72–0.80) < 0.001
 ≥ 91 0.93 (0.86–1.01) 0.067 0.63 (0.58–0.70) < 0.001
Sex
 Female 1 (reference) 1.00 1 (reference) 1.00
 Male 1.16 (1.14–1.19) < 0.001 1.21 (1.17–1.24) < 0.001
Race
 White 1 (reference) 1.00 1 (reference) 1.00
 Black 1.33 (1.29–1.38) < 0.001 1.10 (1.06–1.14) < 0.001
 Others 0.96 (0.92–0.99) 0.040 0.82 (0.78–0.86) < 0.001
 Unknown 0.24 (0.19–0.29) < 0.001 0.18 (0.15–0.23) < 0.001
Marital status
 Unmarried 1 (reference) 1.00 1 (reference) 1.00
 Married 0.84 (0.82–0.86) < 0.001 0.98 (0.95–1.01) 0.151
 Unknown 0.69 (0.65–0.72) < 0.001 0.74 (0.69–0.78) < 0.001
Insurance status
 Insured 1 (reference) 1.00 1 (reference) 1.00
 Any Medic aid 1.45 (1.40–1.49) < 0.001 1.16 (1.12–1.21) < 0.001
 Uninsured 1.78 (1.68–1.88) < 0.001 1.32 (1.23–1.41) < 0.001
 Unknown NA NA NA NA
Site
 Right colon 1 (reference) 1.00 1 (reference) 1.00
 Left colon 1.28 (1.25–1.32) < 0.001 1.18 (1.14–1.22) < 0.001
 Rectum 0.99 (0.96–1.02) 0.628 0.84 (0.81–0.87) < 0.001
 Unknown 5.50 (5.21–5.80) < 0.001 2.03 (1.90–2.17) < 0.001
Histological grade
 Grade I 1 (reference) 1.00 1 (reference) 1.00
 Grade II 2.19 (2.07–2.31) < 0.001 1.81 (1.70–1.92) < 0.001
 Grade III 3.54 (3.33–3.77) < 0.001 2.10 (1.96–2.25) < 0.001
 Grade IV 3.23 (2.96–3.52) < 0.001 1.92 (1.75–2.12) < 0.001
 Unknown 7.13 (6.72–7.56) < 0.001 3.24 (3.04–3.47) < 0.001
Lymphatic metastasis
 N0 1 (reference) 1.00 1 (reference) 1.00
 N1 2.69 (2.61–2.77) < 0.001 0.29 (0.26–0.31) < 0.001
 N2 3.64 (3.52–3.76) < 0.001 0.63 (0.60–0.66) < 0.001
 Unknown 10.50 (10.05–10.96) < 0.001 1.10 (1.05–1.16) < 0.001
T stage
 T1 1 (reference) 1.00 1 (reference) 1.00
 T2 0.35 (0.32–0.38) < 0.001 3.15 (3.04–3.26) < 0.001
 T3 1.50 (1.44–1.56) < 0.001 4.22 (4.04–4.40) < 0.001
 T4 3.62 (3.46–3.78) < 0.001 3.54 (3.36–3.73) < 0.001
 Unknown 8.11 (7.77–8.46) < 0.001 3.15 (3.04–3.26) < 0.001
CEA
 Negative 1 (reference) 1.00 1 (reference) 1.00
 Positive 9.16 (8.81–9.52) < 0.001 6.63 (6.37–6.91) < 0.001
 Unknown 2.15 (2.07–2.24) < 0.001 1.57 (1.51–1.64) < 0.001
  1. CEA carcinoembryonic antigen, NA not available
  2. aIncludes American Indian/Alaska Native and Asian or Pacific Islander
  3. bIncludes single, separated, widowed, and divorced