Table 5 Univariate and multivariate analysis for disease-free survival after the first pulmonary metastasectomy

Age > 50 years

0.464

Liver cirrhosis (+)

0.173

Hepatitis viral marker (+)

0.627

BCLC stage ≥ C

0.072

ECOG performance status ≥1

0.161

Child-Pugh score ≥ B

0.120

Local recurrence of HCC

< 0.001

2.717 (1.694–4.357)

< 0.001

Initial AFP > 500 ng/ml

0.910

Preoperative AFP > 500 ng/ml

0.037

Wedge resection as a metastasectomy

0.199

Multiple PM

0.265

Maximum diameter of PM > 2 cm

0.387

Hospital days ≥ 7

0.044

Time-to-pulmonary recurrence period

0.068

1.852 (1.204–2.848)

0.005

Open metastasectomy

0.943