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Table 4 Anatomical pathology findings comparison between TA (group A) and APA (group B)

From: Atypical parathyroid adenoma: clinical and anatomical pathologic features

  Group A
typical adenoma
Group B
atypical adenoma
P value
n = 107 n = 10
Single gland disease 100 (93.5) 10 (100.0) 1.000
Double typical adenoma 7 (6.5) 0(0.0) 1.000
Size of parathyroid gland (mm) a 23 ± 13 25 ± 30 0.001
Weight of parathyroid gland (mg) 40 ± 16 120 ± 64 <  0.001
Clinical/intraoperative adherence 0 (0.0) 0 (0.0)
Pseudocapsular invasion 0 (0.0) 4 (40.0) <  0.001
Bands of fibrosis 4 (3.7) 5 (50.0) < 0.001
Pronounced trabecular growth 7 (6.5) 6 (60.0) < 0.001
Mitotic rates of > 1/10 HPFS 2 (1.9) 6 (60.0) < 0.001
Tumor necrosisb 0 (0.0) 1 (10.0) 0.085
Nuclear pleomorphism 2 (1.9) 2 (20.0) 0.036
Cystic degeneration 8 (7.5) 2 (20.0) 0.204
Thick capsule 0 (0.0) 4 (40.0) < 0.001
Hemosiderin deposition 3 (2.8) 2 (20.0) 0.058
Hematic extravasion 5 (4.7) 2 (20.0) 0.110
Ki-67+ < 1% 11 (10.3) 0 (0.0) 0.598
Ki-67+ > 4% 0 (0.0) 4 (40.0) < 0.001
Galactin-3 + 22 (20.6) 7 (70.0) 0.002
PGP 9.5 + 13 (12.1) 4 (40.0) 0.038
  1. Data are show as mean ± standard deviation or number (%)
  2. Abbreviations: HPFS high-power fields
  3. aMaximum diameter
  4. bNot associated with tumorous infarction or fine-needle aspiration