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Table 3 Comparison between patients diagnosed with TA (group A) and patients diagnosed with APA (group B)

From: Atypical parathyroid adenoma: clinical and anatomical pathologic features

  Group A
typical adenoma
Group B
atypical adenoma
P-value
n = 107 n = 10
Male n (%) 30 (28.0) 5 (50.0) 0.105
Age (year) 60 ± 13 62 ± 13 0.661
BMI (kg/m2) 25.4 ± 4.0 26.4 ± 3.6 0.258
Symptomatic hypercalcemia 13 (12.1) 6 (60.0) 0.001
Nephrolithiasis 34 (31.8) 2 (20.0) 0.722
Peptic ulcers 2 (1.9) 1 (10.0) 0.237
Pancreatitis 3 (2.8) 2 1.9) 0.304
Cardiovascular disease 16 (15.0) 2 (20.0) 0.651
Hypertension 53 (49.5) 2 (20.0) 0.101
Osteoporosis 24 (22.4) 3 (30.0) 0.695
Fragility fracture 1 (0.9) 2 (20.0) 0.019
Neuropsychiatric/neurocognitive symptoms 6 (5.6) 1 (10.0) 0.474
Neuromuscular symptoms 5 (4.7) 1 10.0) 0.422
CrCl < 60 ml/min 10 (9.3) 1 (10.0) 1.000
Others symptoms 14 (13.1) 2 (20.0) 0.625
Serum creatinine (mg/dL) 1.2 ± 0.7 1.1 ± 0.7 0.750
eGFR (mL/min) 89.2 ± 38.7 89.9 ± 33.3 0.884
Preoperative serum calcium (mg/dL) 11.7 ± 2.1 13.6 ± 1.5 0.001
25-OH vitamin D (ng/mL) 53.2 ± 15.8 56.8 ± 13.4 0.372
24-h urinary calcium 269.9 ± 102.8 376.8 ± 160.7 0.036
Preoperatve iPTH (pg/ml) 390.1 ± 473.6 1198.7 ± 1168.7 0.002
Intraoperative iPTH (pg/ml) 56.6 ± 68.9 93.1 ± 88.9 0.108
Postoperative iPTH (pg/ml) 24.8 ± 16.8 31.4 ± 22.2 0.099
6 mounths iPTH (pg/ml) 23.0 ± 10.0 22.3 ± 6.4 0.696
I Postoperative day serum calcium (mg/dL) 9.1 ± 0.6 9.2 ± 0.6 0.488
II Postoperative day serum calcium (mg/dL) 9.1 ± 0.6 8.9 ± 0.6 0.111
III Postoperative day serum calcium (mg/dL) 8.9 ± 0.4 8.8 ± 0.6 0.747
Follow-up time (mounths) 60 ± 2 61 ± 4 0.551
Temporary hypoparathyroidism 6 (5.6) 1 (10.0) 0.474
Permanent hypoparathyroidism 0 (0.0) 0 (0.0)
Persistent hyperparathyroidism 0 (0.0) 0 (0.0)
  1. Data are shown as mean ± standard deviation or number (%)
  2. Abbreviations: TA typical adenoma, APA atypical parathyroid adenoma, BMI body mass index, CrCl creatinine clearance, eGFR estimated glomerular filtration rate, 25-OH vitamin D 25-hydroxyvitamin D3, iPTH intact-parathyroid hormone, PTX 6 months iPTH iPTH measurement 6 months later the surgery intervention