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Table 3 Comparison between patients diagnosed with TA (group A) and patients diagnosed with APA (group B)

From: Atypical parathyroid adenoma: clinical and anatomical pathologic features

 

Group A

typical adenoma

Group B

atypical adenoma

P-value

n = 107

n = 10

Male n (%)

30 (28.0)

5 (50.0)

0.105

Age (year)

60 ± 13

62 ± 13

0.661

BMI (kg/m2)

25.4 ± 4.0

26.4 ± 3.6

0.258

Symptomatic hypercalcemia

13 (12.1)

6 (60.0)

0.001

Nephrolithiasis

34 (31.8)

2 (20.0)

0.722

Peptic ulcers

2 (1.9)

1 (10.0)

0.237

Pancreatitis

3 (2.8)

2 1.9)

0.304

Cardiovascular disease

16 (15.0)

2 (20.0)

0.651

Hypertension

53 (49.5)

2 (20.0)

0.101

Osteoporosis

24 (22.4)

3 (30.0)

0.695

Fragility fracture

1 (0.9)

2 (20.0)

0.019

Neuropsychiatric/neurocognitive symptoms

6 (5.6)

1 (10.0)

0.474

Neuromuscular symptoms

5 (4.7)

1 10.0)

0.422

CrCl < 60 ml/min

10 (9.3)

1 (10.0)

1.000

Others symptoms

14 (13.1)

2 (20.0)

0.625

Serum creatinine (mg/dL)

1.2 ± 0.7

1.1 ± 0.7

0.750

eGFR (mL/min)

89.2 ± 38.7

89.9 ± 33.3

0.884

Preoperative serum calcium (mg/dL)

11.7 ± 2.1

13.6 ± 1.5

0.001

25-OH vitamin D (ng/mL)

53.2 ± 15.8

56.8 ± 13.4

0.372

24-h urinary calcium

269.9 ± 102.8

376.8 ± 160.7

0.036

Preoperatve iPTH (pg/ml)

390.1 ± 473.6

1198.7 ± 1168.7

0.002

Intraoperative iPTH (pg/ml)

56.6 ± 68.9

93.1 ± 88.9

0.108

Postoperative iPTH (pg/ml)

24.8 ± 16.8

31.4 ± 22.2

0.099

6 mounths iPTH (pg/ml)

23.0 ± 10.0

22.3 ± 6.4

0.696

I Postoperative day serum calcium (mg/dL)

9.1 ± 0.6

9.2 ± 0.6

0.488

II Postoperative day serum calcium (mg/dL)

9.1 ± 0.6

8.9 ± 0.6

0.111

III Postoperative day serum calcium (mg/dL)

8.9 ± 0.4

8.8 ± 0.6

0.747

Follow-up time (mounths)

60 ± 2

61 ± 4

0.551

Temporary hypoparathyroidism

6 (5.6)

1 (10.0)

0.474

Permanent hypoparathyroidism

0 (0.0)

0 (0.0)

–

Persistent hyperparathyroidism

0 (0.0)

0 (0.0)

–

  1. Data are shown as mean ± standard deviation or number (%)
  2. Abbreviations: TA typical adenoma, APA atypical parathyroid adenoma, BMI body mass index, CrCl creatinine clearance, eGFR estimated glomerular filtration rate, 25-OH vitamin D 25-hydroxyvitamin D3, iPTH intact-parathyroid hormone, PTX 6 months iPTH iPTH measurement 6 months later the surgery intervention