Table 1 Characteristics of the studies assessing ALDH2 rs671 and HCC susceptibility
Author | Country | Year | Cases | Controls | HWE | Genotyping method | Virus infection | Quality score | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Total | GG | GA | AA | Total | GG | GA | AA | Cases | Controls | ||||||
Takeshita | Japan | 2000 | 102 | 62 | 38 | 2 | 125 | 65 | 49 | 11 | Yes | PCR-RFLP | 8 with HBsAg (+); 71 with HCV antibody (+) | HBsAg (+), 0%; HCV antibody (+), 0% | 7 |
Koide | Japan | 2000 | 84 | 48 | 32 | 4 | 84 | 43 | 33 | 8 | Yes | PCR-RFLP | HBsAg (+), 14.5%; anti-HCV (+), 81.9% | HBsAg (+), 0%; anti-HCV (+), 7.1% | 6 |
Yu | China | 2002 | 132 | 67 | 51 | 14 | 134 | 58 | 63 | 13 | Yes | PCR | HBsAg (+), 67.9%; anti-HCV (+), 5.2% | HBsAg (+), 15.7%; anti-HCV (+), 6.0% | 8 |
Munaka | Japan | 2003 | 78 | 34 | 44 (GA + AA) | 138 | 76 | 62 (GA + AA) | Yes | PCR | HBsAg (+), 17.9%; anti-HCV (+), 69.2% | HBsAg (+), 0.7%; anti-HCV (+), 7.3% | 8 | ||
Kato | Japan | 2003 | 94 | 75 (GG + GA) | 19 | 133 | 127 (GG + GA) | 6 | Yes | PCR-RFLP | HBsAg (+), not reported; anti-HCV (+), 100% | HBsAg (+), not reported; anti-HCV (+), 0% | 7 | ||
Sakamoto | Japan | 2006 | 209 | 117 | 77 | 15 | 275 | 146 | 107 | 22 | Yes | PCR-CTPP | HBsAg (+), 9.1%; anti-HCV (+), 85.6% | HBsAg (+), 2.2%; anti-HCV (+), 7.6% | 8 |
Ding | China | 2008 | 208 | 120 | 64 | 24 | 207 | 133 | 59 | 15 | No | PCR-RFLP | HBsAg (+), 72.1%; anti-HCV (+), not reported | HBsAg (+), 22.2%; anti-HCV (+), not reported | 8 |
Tomoda | Japan | 2012 | 264 | 132 | 111 | 21 | 199 | 126 | 60 | 13 | Yes | PCR | HBsAg (+), 0%; anti-HCV (+), 100% | HBsAg (+), 0%; anti-HCV (+), 100% | 6 |
Abe | Japan | 2015 | 67 | 51 | 16 | 0 | 67 | 62 | 5 | 0 | Yes | PCR-CTPP | HBsAg (+), 0%; anti-HCV (+), 0% | HBsAg (+), 0%; anti-HCV (+), 0% | 8 |
Liu | China | 2016 | 600 | 303 | 248 | 49 | 3221 | 1617 | 1354 | 250 | Yes | PCR | HBsAg (+), 100%; anti-HCV (+), 0% | HBsAg (+), 100%; anti-HCV (+),0% | 7 |
Ye | China | 2018 | 300 | 149 | 121 | 30 | 292 | 152 | 119 | 21 | Yes | PCR-RFLP | HBsAg (+), 85.0%; anti-HCV (+), not reported | HBsAg (+), 10.3%; anti-HCV (+), not reported | 8 |