Table 2 Analysis of predictive factors of regional and/or distant RD (RDRD). Fisher’s exact test and univariate logistic regression. Patients with unknown data had no significant differences regarding the risk of RDRD, compared to patients in the reference categories. This rules out bias due to missing values
% Regional and/or distant residual disease | P | RR (CI 95%) | P | |
|---|---|---|---|---|
Cholecystectomy | 0.975 | 0.975 | ||
Urgent | 7/16 (43) | 1.02 (0.37–3.38) | ||
Elective | 17/43 (39.5) | REF | ||
Surgical approach | 0.138 | 0.142 | ||
Open or converted | 10/19 (52.6) | 2.03 (0.755–7.05) | ||
Laparoscopic | 13/40 (32.5) | REF | ||
Cystic margin invasion | 0.658 | 0.660 | ||
Yes | 7/16 (43.8) | 1.10 (0.25–4.79) | ||
Unknown | 6/13 (46.2) | 0.64 (0.18–2.23) | ||
No | 10/30 (33.3) | REF | ||
T-stage | 0.003 | 0.021 | ||
T3 | 7/8 (87.5) | 13.12 (1.48–116.26) | ||
T2 | 16/46 (34.8) | REF | ||
Tis + T1a + T1b | 0/5 (0) | – | ||
Positive lymph nodes | 0.412 | 0.420 | ||
N+ | 8/15 (53.3) | 2.00 (0.40–9.83) | ||
Unknown | 11/33 (33.3) | 0.87 (0.21–3.64) | ||
N0 | 4/15 (36.4) | REF | ||
Grade | 0.691 | 0.698 | ||
Poorly | 2/7 (28.6) | 1.06 (0.12–8.79) | ||
Moderately | 11/24 (45.8) | 2.25 (0.47–10.64) | ||
Unknown | 7/17 (41.2) | 1.86 (0.36–9.63) | ||
Well | 3/11 (27.3) | REF | ||
Histology | 0.241 | 0.247 | ||
Other | 6/11 (54.5) | 2.18 (0.58–8.24) | ||
Adenocarcinoma | 17/38 (35.4) | REF | ||
Lymphovascular invasion | 0.005 | 0.010 | ||
Yes | 11/15 (73.3) | 6.05 (1.54–23.73) | ||
Unknown | 2/12 (16.7) | 0.44 (0.81–2.39) | ||
No | 10/32 (31.3) | REF | ||
Perineural invasion | 0.016 | 0.024 | ||
Yes | 11/16 (68.8) | 6.16 (1.41–26.75) | ||
Unknown | 7/24 (29.2) | 1.15 (0.29–4.3) | ||
No | 5/19 (26.3) | REF |