Table 1 Demographic characteristics of the complete series, pathologic data from the cholecystectomy specimen, and operative data at re-resection. Comparison with the Ethun et al. series [16]
Ramos et al., n = 59 | Ethun et al., n = 262 | P (unknown excluded) | ||
|---|---|---|---|---|
Age (years), mean (SD) | 65 (9.6) | 65 (11.6) | 1 | |
Sex, M/F | 18/41 | |||
ASA, I/II/III/IV | 17/32/9/1 | |||
Cholecystectomy, urgent/elective | 15/44 | |||
Surgical approach, open or converted/laparoscopic | 19/40 | |||
T-stage, n (%) | Unknown | – | 36 (13.7) | < 0.001 |
T(1a + 1b) | 5 (8.5) | 22 (8.3) | ||
T2 | 46 (78) | 113 (43) | ||
T3/T4 | 8 (13.6) | 91 (34.7) | ||
N, N0/N1/unknown | 11/15/33 | |||
Affected cystic margin, Y/N/unknown | 16/30/13 | |||
Grade of differentiation n (%) | Unknown | 17 (29) | 67 (25.5) | 0.040 |
Well | 11 (18.3) | 24 (9.1) | ||
Moderately | 24 (40) | 115 43.8) | ||
Poorly | 7 (11.7) | 56 (21.3) | ||
Histology, adenocarcinoma/other | 48/11 | |||
Lymphovascular invasion, n (%) | Unknown | 12 (20.3) | 149 (57) | 0.136 |
No | 32 (54.2) | 61 (23.2) | ||
Yes | 15 (5.4) | 52 (19.8) | ||
Perineural invasion, n (%) | Unknown | 24 (40.7) | 145 (55.3) | |
No | 19 (32.2) | 55 (21) | 0.369 | |
Yes | 16 (27.1) | 62 (23.6) | ||
GBRS | Unknown | 34/59 | 174/262 | |
High | 5 (20) | 42 (48) | 0.030 | |
Intermediate | 20 (80) | 42 (48) | ||
Low | 0 | 4 (4) | ||
Time to reoperation (weeks), mean (SD) | 12.4 (6.2) | 9.3 (14.3) | 0.010 | |
Completed re-resection, n (%) | 49 (83) | 214 (82) | 0.804 | |
Liver resection, n (%) | 46/49 (94) | 191 (89) | 0.327 | |
Common bile duct resection, n (%) | 23/49 (47) | 73 (34) | 0.092 | |
Port-site excision, n (%) | 16/49 (32) | 87 (40) | 0.677 | |
Final margin status R0, n (%) | 44 (74.5) | 196 (75) | 0.974 | |
RD at reoperation, n (%) | 30 (50.8) | 174 (66.4) | 0.05 | |
Local or regional | 21 (35.5) | 129 (49.2) | ||
Distant | 9 (15.3) | 45 (17.2) | ||
Final TNM staging, 7th ed. | 0,I/II/IIIa,IIIb,IV | 5/22/32 |