Prognosis analysis of patients with pancreatic neuroendocrine tumors after surgical resection and the application of enucleation

Table 5 The Multivariable Cox proportional hazards regression model was applied to investigate the roles of different surgery on OS/CSS for G1 p-NETs with diameter ≤ 4 cm

Characteristics		Multivariate analysis (OS)	P	Multivariate analysis (CSS)	P
Characteristics	N = 1387	Hazard ratio (95% CI)		Hazard ratio (95% CI)
Gender
Male	685	1 (reference)		1 (reference)
Female	702	0.635 (0.403-1.001)	0.050	0.844 (0.470-1.516)	0.570
Year of diagnosis
2004-2009	126	1 (reference)		1 (reference)
2010-2017	1261	1.697 (0.868-3.316)	0.122	1.376 (0.591-3.203)	0.460
Location Of tumor
Head of pancreas	406	1 (reference)		1 (reference)
Body/tail of pancreas	854	0479 (0.260-0.881)	0.018	0.502 (0.213-1.187)	0.117
Other^a	127	0.880 (0.397-1.952)	0.753	1.082 (0.376-3.111)	0.884
Surgery
Enucleation	129	1 (reference)		1 (reference)
Partial pancreatectomy	938	3.254 (0.747-14.176)	0.116	3.246 (0.403-26.158)	0.269
Pancreaticoduodenectomy	235	4.945 (1.080-22.637)	0.039	10.641 (1.270-89.181)	0.029
Total pancreatectomy	85	5.862 (1.210-28.396)	0.028	10.310 (1.164-91.352)	0.036
AJCC 8^th stage
I	505	1 (reference)		1 (reference)
II	282	1.989 (1.041-3.798)	0.037	1.766 (0.710-4.391)	0.221
III	310	1.774(0.951-3.312)	0.072	1.955 (0.858-4.455)	0.111
Unknown	290	1.742 (0.809-3.754)	0.156	2.385 (0.842-6.752)	0.102
Race
White	1051	1 (reference)		1 (reference)
Black	173	1.402 (0.731-2.689)	0.310	1.056 (0.410-2.720)	0.911
Other^b	163	0.727 (0.330-1.601)	0.428	0.799 (0.310-2.057)	0.642
Age at diagnosis (year)
≤ 60	844	1 (reference)		1 (reference)
> 60	543	1.866 (1.192-2.921)	0.006	1.998 (1.107-3.803)	0.022

^aOverlapping lesion of the pancreas, pancreatic duct, and other specified parts of the pancreas
^bAsian/American Indian/Alaska Native/Pacific Islander

ISSN: 1477-7819