Is left-sided involvement of hepatocellular carcinoma an important preoperative predictive factor of poor outcome?

Table 3 Associations between cumulative death proportions and clinical factors demonstrated by univariable and multivariable analyses

		Univariable analysis				Multivariable analysis (only preoperative factors)
		HR	95% CI		p value	HR	95% CI			p value^a
Age	Continuous	1.018	1.004–1.031		0.010	1.018	1.002–1.033			0.019
Sex	Female	Ref				Ref
	Male	0.844	0.642–1.109		0.220	1.049	0.785–1.402			0.745
Location	RGS	Ref				Ref
	LGS	1.34	1.055–1.702		0.018	1.371	1.073–1.752			0.012
Resection type	Anatomical resection	Ref				Ref
	Non-anatomical resection	1.407	1.119–1.768		0.003	–	–	–	–	–
ICGR	Continuous	1.019	1.008–1.03		0.001	1.018	1.007–1.030			0.002
AFP, ng/mL	< 13	Ref
	> 13.1	1.804	1.413–2.302		< 0.001	1.777	1.384–2.282			< 0.001
PIVKA2, ng/mL	< 40	Ref
	> 41	1.597	1.267–2.012		< 0.001	1.256	0.972–1.623			0.082
Tumor size, cm	< 5	Ref
	> 5.1	2.134	1.647–2.766		< 0.001	1.949	1.470–2.582			< 0.001
Operative time, min	< 270	Ref		–
	> 271	1.708	1.350–2.162		< 0.001	–	–	–	–	–
Blood loss, ml	< 300	Ref		–
	> 301	1.590	1.216–2.079		0.001	–	–	–	–	–
HBV	Negative	Ref		–
	Positive	0.697	0.487–0.998		0.049	0.943	0.635–1.400			0.771
HCV	Negative	Ref		–
	Positive	1.083	0.850–1.380		0.518	–	–	–	–	–
Hepatic vein invasion	Negative	Ref		–
	Positive	2.180	1.350–3.518		0.001	–	–	–	–	–
Portal vein invasion	Negative	Ref		–
	Positive	1.705	1.340–2.171		< 0.001	–	–	–	–	–

HR hazard ratios, 95%CI 95% confidence interval
^aInput criteria for multiple analysis were preoperative factors with p < 0.05 in univariate analysis with age and sex

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