CSS | OS | ||||||
---|---|---|---|---|---|---|---|
Variable | Number | Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | ||
p value | HR (95%CIs) | p value | p value | HR (95%CIs) | p value | ||
NLNs | |||||||
≤ 5 | 3850 | 1 (reference) | 1 (reference) | ||||
> 5 | 3443 | < 0.001 | 0.791 (0.710–0.882) | < 0.001 | < 0.001 | 0.821 (0.763–0.884) | < 0.001 |
Sex | |||||||
Male | 3040 | 1 (reference) | 1 (reference) | ||||
Female | 4253 | < 0.001 | 0.757 (0.686–0.835) | < 0.001 | < 0.001 | 0.723 (0.676–0.773) | < 0.001 |
Age | |||||||
≤ 65 | 2985 | 1 (reference) | 1 (reference) | ||||
> 65 | 4308 | < 0.001 | 1.548 (1.393–1.720) | < 0.001 | < 0.001 | 1.946 (1.806–2.096) | < 0.001 |
TNM stage | |||||||
IA1 | 1244 | 1 (Reference) | 1 (Reference) | ||||
IA2 | 6049 | 0.003 | 1.023 (0.843–1.243) | 0.815 | < 0.001 | 1.038 (0.911–1.182) | 0.578 |
Grade | |||||||
I | 1615 | 1 (reference) | 1 (reference) | ||||
II | 3191 | < 0.001 | 2.109 (1.794–2.479) | < 0.001 | < 0.001 | 1.631 (1.471–1.807) | < 0.001 |
III | 1839 | < 0.001 | 2.810 (2.364–3.341) | < 0.001 | < 0.001 | 2.004 (1.792–2.242) | < 0.001 |
IV | 92 | < 0.001 | 1.476 (0.911–2.392) | 0.113 | < 0.001 | 1.303 (0.944–1.797) | 0.107 |
Unknown | 556 | < 0.001 | 1.785 (1.414–2.253) | < 0.001 | < 0.001 | 1.407 (1.207–1.640) | < 0.001 |
Tumor location (%) | |||||||
Upper lobe | 4547 | 1 (Reference) | |||||
Middle lobe | 459 | 0.597 | 0.017 | 0.895 (0.773–1.036) | 0.138 | ||
Lower lobe | 2181 | 0.794 | 0.712 | 1.038 (0.964–1.119) | 0.320 | ||
Main bronchus | 9 | 0.427 | 0.351 | 0.800 (0.257–2.485) | 0.699 | ||
Overlapping | 28 | 0.821 | 0.431 | 1.429 (0.859–2.378) | 0.169 | ||
Lung NOS | 69 | 0.176 | 0.148 | 1.114 (0.811–1.530) | 0.506 | ||
Tumor size (mm) | – | < 0.001 | 1.022 (1.004–1.041) | 0.015 | < 0.001 | 1.018 (1.005–1.030) | 0.005 |
Race | |||||||
American Indian | 29 | 1 (Reference) | |||||
Asian | 397 | 0.725 | 0.160 | 0.613 (0.346–1.083) | 0.092 | ||
Black | 563 | 0.410 | 0.742 | 0.962 (0.551–1.679) | 0.890 | ||
White | 6291 | 0.548 | 0.747 | 0.920 (0.533–1.587) | 0.764 | ||
Unknown | 13 | 0.981 | 0.049 | 0.150 (0.020–1.150) | 0.068 | ||
Surgical methods | |||||||
Wedge resection | 1647 | 1 (reference) | 1 (reference) | ||||
Segmental resection | 364 | 0.397 | 0.944 (0.757–1.178) | 0.610 | 0.009 | 0.841 (0.721–0.981) | 0.027 |
Lobectomy | 5228 | < 0.001 | 0.719 (0.637–0.812) | < 0.001 | < 0.001 | 0.696 (0.641–0.756) | < 0.001 |
Pneumonectomy | 45 | 0.033 | 1.957 (1.183–3.238) | 0.009 | 0.030 | 1.623 (1.137–2.315) | 0.008 |
Unknown | 6 | 0.426 | 0.430 (0.060–3.061) | 0.399 | 0.284 | 0.567 (0.182–1.763) | 0.327 |
Histological types | |||||||
Adeno | 4800 | 1 (reference) | 1 (reference) | ||||
SCC | 1606 | < 0.001 | 1.046 (0.926–1.182) | 0.470 | < 0.001 | 1.376 (1.271–1.490) | < 0.001 |
LCC | 191 | < 0.001 | 1.666 (1.276–2.175) | < 0.001 | < 0.001 | 1.533 (1.257–1.869) | < 0.001 |
PSC | 5 | 0.012 | 2.516 (0.808–7.832) | 0.111 | 0.036 | 1.691 (0.633–4.517) | 0.294 |
Other | 432 | 0.011 | 1.241 (1.014–1.518) | 0.036 | 0.020 | 1.140 (0.984–1.321) | 0.080 |
Unknown | 259 | 0.008 | 0.971 (0.755–1.247) | 0.815 | < 0.001 | 1.135 (0.961–1.339) | 0.136 |