Skip to main content

Table 2 The association between NLNs and CSS together with OS in univariate and multivariate analyses without PSM

From: Association between number of dissected lymph nodes and survival in stage IA non-small cell lung cancer: a propensity score matching analysis

 

CSS

OS

Variable

Number

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

p value

HR (95%CIs)

p value

p value

HR (95%CIs)

p value

NLNs

 ≤ 5

3850

 

1 (reference)

  

1 (reference)

 

 > 5

3443

< 0.001

0.791 (0.710–0.882)

< 0.001

< 0.001

0.821 (0.763–0.884)

< 0.001

Sex

 Male

3040

 

1 (reference)

  

1 (reference)

 

 Female

4253

< 0.001

0.757 (0.686–0.835)

< 0.001

< 0.001

0.723 (0.676–0.773)

< 0.001

Age

 ≤ 65

2985

 

1 (reference)

  

1 (reference)

 

 > 65

4308

< 0.001

1.548 (1.393–1.720)

< 0.001

< 0.001

1.946 (1.806–2.096)

< 0.001

TNM stage

 IA1

1244

 

1 (Reference)

  

1 (Reference)

 

 IA2

6049

0.003

1.023 (0.843–1.243)

0.815

< 0.001

1.038 (0.911–1.182)

0.578

Grade

 I

1615

 

1 (reference)

  

1 (reference)

 

 II

3191

< 0.001

2.109 (1.794–2.479)

< 0.001

< 0.001

1.631 (1.471–1.807)

< 0.001

 III

1839

< 0.001

2.810 (2.364–3.341)

< 0.001

< 0.001

2.004 (1.792–2.242)

< 0.001

 IV

92

< 0.001

1.476 (0.911–2.392)

0.113

< 0.001

1.303 (0.944–1.797)

0.107

 Unknown

556

< 0.001

1.785 (1.414–2.253)

< 0.001

< 0.001

1.407 (1.207–1.640)

< 0.001

Tumor location (%)

 Upper lobe

4547

    

1 (Reference)

 

 Middle lobe

459

0.597

  

0.017

0.895 (0.773–1.036)

0.138

 Lower lobe

2181

0.794

  

0.712

1.038 (0.964–1.119)

0.320

 Main bronchus

9

0.427

  

0.351

0.800 (0.257–2.485)

0.699

 Overlapping

28

0.821

  

0.431

1.429 (0.859–2.378)

0.169

 Lung NOS

69

0.176

  

0.148

1.114 (0.811–1.530)

0.506

Tumor size (mm)

–

< 0.001

1.022 (1.004–1.041)

0.015

< 0.001

1.018 (1.005–1.030)

0.005

Race

 American Indian

29

    

1 (Reference)

 

 Asian

397

0.725

  

0.160

0.613 (0.346–1.083)

0.092

 Black

563

0.410

  

0.742

0.962 (0.551–1.679)

0.890

 White

6291

0.548

  

0.747

0.920 (0.533–1.587)

0.764

 Unknown

13

0.981

  

0.049

0.150 (0.020–1.150)

0.068

Surgical methods

 Wedge resection

1647

 

1 (reference)

  

1 (reference)

 

 Segmental resection

364

0.397

0.944 (0.757–1.178)

0.610

0.009

0.841 (0.721–0.981)

0.027

 Lobectomy

5228

< 0.001

0.719 (0.637–0.812)

< 0.001

< 0.001

0.696 (0.641–0.756)

< 0.001

 Pneumonectomy

45

0.033

1.957 (1.183–3.238)

0.009

0.030

1.623 (1.137–2.315)

0.008

 Unknown

6

0.426

0.430 (0.060–3.061)

0.399

0.284

0.567 (0.182–1.763)

0.327

Histological types

 Adeno

4800

 

1 (reference)

  

1 (reference)

 

 SCC

1606

< 0.001

1.046 (0.926–1.182)

0.470

< 0.001

1.376 (1.271–1.490)

< 0.001

 LCC

191

< 0.001

1.666 (1.276–2.175)

< 0.001

< 0.001

1.533 (1.257–1.869)

< 0.001

 PSC

5

0.012

2.516 (0.808–7.832)

0.111

0.036

1.691 (0.633–4.517)

0.294

 Other

432

0.011

1.241 (1.014–1.518)

0.036

0.020

1.140 (0.984–1.321)

0.080

 Unknown

259

0.008

0.971 (0.755–1.247)

0.815

< 0.001

1.135 (0.961–1.339)

0.136

  1. NSCLC non-small cell lung cancer, NLNs the number of removed lymph nodes, PSM propensity score matching, HR hazard ratio, CIs confident intervals, Lung NOS uncertain location on lung, Adeno adenocarcinoma, SCC squamous cell carcinoma, LCC large cell carcinoma, PSC pulmonary sarcomatoid carcinoma, Other other histological types
Back to article page

World Journal of Surgical Oncology

ISSN: 1477-7819

Contact us