Skip to main content

Table 3 CRP and WBC means between POD 2 and 4, with respect to patients’ complications status, and their respective clinical significance when present (p < 0.05). The PPV, NPV, Se, and Spe for the CRP thresholds p50 (median) and p25, are also shown

From: Postoperative C-reactive protein kinetics predict postoperative complications in patients treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis

Patients Characteristics WBC Mean between POD 2 and POD 4 p-value CRP Mean between POD 2 and POD 4 p-value p50 (cut-off = 106.1) p25 (cut-off = 56.5)
Without Complications 8.23   45,79   Se: 65.57% Se: 85.25%
vs   p > 0,05   p < 0,0001 Spe: 46.15% Spe: 46.17%
With Complications 9.46   124,3   PPV:67.44% PPV: 78.79%
NPV:66.67% NPV: 57.14%
Without Complication    45,79    
vs       
CD 1–2 N/A N/A 80,06 p < 0,0001 N/A N/A
vs       
CD 3–4    162,4    
Without Complications 8.23   45,79   Se: 57.1% Se: 85.7%
vs   p > 0,05   p = 0,0004 Spe: 78.6% Spe: 53.6%
Infectious Complications 9.2   107,0   PPV: 76.9% PPV: 69.8%
NPV: 59.5% NPV: 75.0%
Without Complications 8.23   45,79   Se: 33.3% Se: 100%
vs   p > 0,05   p = 0,0163 Spe: 78.6% Spe: 53.6%
Non-Infectious Complications 9.8   107,5   PPV: 14.3% PPV: 18.8%
NPV: 91.7% NPV: 100%
  1. (CRP C-reactive protein, WBC White blood cells, POD Postoperative day, PPV Positive Predictive Value, NPV Negative Predictive Value, Se Sensitivity, Spe Specificity)