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Table 3 CRP and WBC means between POD 2 and 4, with respect to patients’ complications status, and their respective clinical significance when present (p < 0.05). The PPV, NPV, Se, and Spe for the CRP thresholds p50 (median) and p25, are also shown

From: Postoperative C-reactive protein kinetics predict postoperative complications in patients treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis

Patients Characteristics

WBC Mean between POD 2 and POD 4

p-value

CRP Mean between POD 2 and POD 4

p-value

p50 (cut-off = 106.1)

p25 (cut-off = 56.5)

Without Complications

8.23

 

45,79

 

Se: 65.57%

Se: 85.25%

vs

 

p > 0,05

 

p < 0,0001

Spe: 46.15%

Spe: 46.17%

With Complications

9.46

 

124,3

 

PPV:67.44%

PPV: 78.79%

NPV:66.67%

NPV: 57.14%

Without Complication

  

45,79

   

vs

      

CD 1–2

N/A

N/A

80,06

p < 0,0001

N/A

N/A

vs

      

CD 3–4

  

162,4

   

Without Complications

8.23

 

45,79

 

Se: 57.1%

Se: 85.7%

vs

 

p > 0,05

 

p = 0,0004

Spe: 78.6%

Spe: 53.6%

Infectious Complications

9.2

 

107,0

 

PPV: 76.9%

PPV: 69.8%

NPV: 59.5%

NPV: 75.0%

Without Complications

8.23

 

45,79

 

Se: 33.3%

Se: 100%

vs

 

p > 0,05

 

p = 0,0163

Spe: 78.6%

Spe: 53.6%

Non-Infectious Complications

9.8

 

107,5

 

PPV: 14.3%

PPV: 18.8%

NPV: 91.7%

NPV: 100%

  1. (CRP C-reactive protein, WBC White blood cells, POD Postoperative day, PPV Positive Predictive Value, NPV Negative Predictive Value, Se Sensitivity, Spe Specificity)