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Table 4 Survival of the pulmonary metastasectomy from CRC in univariate analysis

From: Prognostic factors in pulmonary metastasectomy and efficacy of repeat pulmonary metastasectomy from colorectal cancer

Prognostic factors n (%) 5-year overall survival after the initial pulmonary metastasectomy (%) p value
Gender Male 85 (67.5) 54.5 0.04*
Female 41 (32.5) 77.0
Age (years)  70 41 (32.5) 53.8 0.34
< 70 85 (67.5) 63.1
Brinkman indexa  400 58 (46.0) 64.5 0.78
< 400 48 (38.1) 59.2
Primary colorectal tumor location Colon 59 (46.8) 53.4 0.31
Rectum 66 (52.4) 69.1
Right-sided 23 (18.2) 57.3 0.50
Left-sided 102 (81.0) 61.3
Histological differentiation of the primary colorectal tumor Well 55 (43.6) 67.3 0.26
Moderately and poorly 59 (46.8) 59.8
Pathological T stageb T4 37 (29.4) 55.2 0.21
T < 4 79 (62.7) 63.9
Pathological N stageb N 1 71 (56.3) 61.6 0.99
N0 43 (34.1) 60.5
Past history of extra thoracic metastasis Presence 45 (35.7) 53.1 0.04*
Absence 81 (64.3) 65.4
Past history of liver metastasis Presence 33 (26.2) 52.4 0.05
Absence 93 (73.8) 64.3
Adjuvant chemotherapy after primary colorectal resection Yes 61 (48.4) 68.5 0.07
No 57 (45.2) 53.9
Diagnosis period of pulmonary metastases Synchronous 41 (32.5) 63.7 0.48
Metachronous 85 (67.5) 59.3
Number of pulmonary metastases Solitary 89 (70.6) 62.2 0.75
Multiple 34 (27.0) 55
Location of pulmonary metastases Unilateral 108 (85.7) 62.9 0.56
Bilateral 18 (14.3) 52.9
Maximum tumor size (mm)  20 27 (21.4) 31.2 0.002**
< 20 94 (74.6) 66.1
Mediastinal lymph node metastasis Positive 5 (4.0) 20.0 0.02*
Negative 117 (74.6) 60.8
Preoperative CEA level Normal 86 (68.3) 67.7 0.01*
Elevated 36 (28.6) 37.3
Preoperative CA19-9 level Normal 97 (77) 64.1 0.03*
Elevated 12 (9.5) 31.8
Disease free interval after primary colorectal resection (years)  2 81 (64.3) 59.9 0.91
< 2 45 (35.7) 62.4
Chemotherapy before pulmonary metastasectomy Yes 28 (22.2) 49.6 0.17
No 96 (76.2) 62.6
Chemotherapy after pulmonary metastasectomy Yes 40 (31.7) 60.6 0.77
No 74 (58.7) 59.7
Repeat pulmonary metastasectomy for pulmonary recurrence Yes 26 (38.8) 76.9 <0.001***
No 41 (61.2) 8.7
  1. CRC colorectal cancer, CEA carcinoembryonic antigen level, normal upper limit at 5 ng/ml , CA19-9 carbohydrate antigen 19-9 level, normal upper limit at 37 ng/ml
  2. aBrinkman index = (the number of cigarette smoked per day) × (the number of years of smoking)
  3. bUICC TNM classification (the 8th edition)
  4. *p < 0.05; **p < 0.01; ***p < 0.001