Prognostic factors | n (%) | 5-year overall survival after the initial pulmonary metastasectomy (%) | p value | |
---|---|---|---|---|
Gender | Male | 85 (67.5) | 54.5 | 0.04* |
Female | 41 (32.5) | 77.0 | ||
Age (years) | ≧ 70 | 41 (32.5) | 53.8 | 0.34 |
< 70 | 85 (67.5) | 63.1 | ||
Brinkman indexa | ≧ 400 | 58 (46.0) | 64.5 | 0.78 |
< 400 | 48 (38.1) | 59.2 | ||
Primary colorectal tumor location | Colon | 59 (46.8) | 53.4 | 0.31 |
Rectum | 66 (52.4) | 69.1 | ||
Right-sided | 23 (18.2) | 57.3 | 0.50 | |
Left-sided | 102 (81.0) | 61.3 | ||
Histological differentiation of the primary colorectal tumor | Well | 55 (43.6) | 67.3 | 0.26 |
Moderately and poorly | 59 (46.8) | 59.8 | ||
Pathological T stageb | T4 | 37 (29.4) | 55.2 | 0.21 |
T < 4 | 79 (62.7) | 63.9 | ||
Pathological N stageb | N ≧ 1 | 71 (56.3) | 61.6 | 0.99 |
N0 | 43 (34.1) | 60.5 | ||
Past history of extra thoracic metastasis | Presence | 45 (35.7) | 53.1 | 0.04* |
Absence | 81 (64.3) | 65.4 | ||
Past history of liver metastasis | Presence | 33 (26.2) | 52.4 | 0.05 |
Absence | 93 (73.8) | 64.3 | ||
Adjuvant chemotherapy after primary colorectal resection | Yes | 61 (48.4) | 68.5 | 0.07 |
No | 57 (45.2) | 53.9 | ||
Diagnosis period of pulmonary metastases | Synchronous | 41 (32.5) | 63.7 | 0.48 |
Metachronous | 85 (67.5) | 59.3 | ||
Number of pulmonary metastases | Solitary | 89 (70.6) | 62.2 | 0.75 |
Multiple | 34 (27.0) | 55 | ||
Location of pulmonary metastases | Unilateral | 108 (85.7) | 62.9 | 0.56 |
Bilateral | 18 (14.3) | 52.9 | ||
Maximum tumor size (mm) | ≧ 20 | 27 (21.4) | 31.2 | 0.002** |
< 20 | 94 (74.6) | 66.1 | ||
Mediastinal lymph node metastasis | Positive | 5 (4.0) | 20.0 | 0.02* |
Negative | 117 (74.6) | 60.8 | ||
Preoperative CEA level | Normal | 86 (68.3) | 67.7 | 0.01* |
Elevated | 36 (28.6) | 37.3 | ||
Preoperative CA19-9 level | Normal | 97 (77) | 64.1 | 0.03* |
Elevated | 12 (9.5) | 31.8 | ||
Disease free interval after primary colorectal resection (years) | ≧ 2 | 81 (64.3) | 59.9 | 0.91 |
< 2 | 45 (35.7) | 62.4 | ||
Chemotherapy before pulmonary metastasectomy | Yes | 28 (22.2) | 49.6 | 0.17 |
No | 96 (76.2) | 62.6 | ||
Chemotherapy after pulmonary metastasectomy | Yes | 40 (31.7) | 60.6 | 0.77 |
No | 74 (58.7) | 59.7 | ||
Repeat pulmonary metastasectomy for pulmonary recurrence | Yes | 26 (38.8) | 76.9 | <0.001*** |
No | 41 (61.2) | 8.7 |