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Table 1 Patients and primary colorectal tumor characteristics in each group (initial and second pulmonary metastasectomy)

From: Prognostic factors in pulmonary metastasectomy and efficacy of repeat pulmonary metastasectomy from colorectal cancer

Characteristics The initial pulmonary metastasectomy
n = 126
The second pulmonary metastasectomy
n = 26
p value
Gender, n (%) Male 85 (67.5)
Female 41 (32.5)
Male 16 (61.5)
Female 10 (38.5)
0.56
Age¶, median [range] 66 [37–84] 62.5 [37–77] 0.04*
Smoking habits, n (%) Non-smoker 39 (31.0) Smoker 79 (62.7) Non-smoker 10 (38.5)
Smoker 13 (50.0)
0.34
Brinkman index✝, median [range] 457.5 [0–2100] 107 [0–2000] 0.46
Primary colorectal tumor location, n (%) Colon 59 (46.8)
Rectum 66 (52.4)
Colon 11 (42.3)
Rectum 16 (57.7)
0.65
Right side 23 (18.2)
Left side 102 (81.0)
Right side 3 (11.5)
Left side 23 (88.5)
0.38
Histological differentiation of the primary colorectal tumor, n (%) Well–55 (43.6)
Moderately–53 (42.0)
Poorly–6 (4.8)
Well–8 (30.8)
Moderately–9 (34.6)
Poorly–1 (3.8)
0.54
Pathological T stage‡, n (%) T1 7 (5.6)
T2 11 (8.7)
T3 61 (48.4)
T4 37 (29.4)
T1 1 (3.8)
T2 0 (0.0)
T3 15 (57.7)
T4 6 (23.1)
0.19
Pathological N stage‡, n (%) N0 43 (34.1)
N1 47 (37.3)
N2 24 (19.0)
N0 7 (27.0)
N1 9 (34.6)
N2 5 (19.2)
0.92
Pathological stage‡, n (%) I 8 (6.3)
II 25 (19.8)
III 56 (44.4)
IV 31 (24.6)
I 0 (0.0)
II 5 (19.2)
III 12 (46.2)
IV 8 (30.8)
0.35
Past history of extra thoracic metastasis, n (%) Present 45 (35.7)
Absent 81 (64.3)
Present 10 (38.5)
Absent 16 (61.5)
0.79
Adjuvant chemotherapy, n (%) Yes 61 (48.4) No 57 (45.2) Yes 16 (61.5) No 8 (30.8) 0.18
Regimen, n (%) UFT 28 (22.2) capecitabine 7 (5.6) CapeOX 7 (5.6) FOLFOX 5 (4.0)
S1 4 (3.2) FU + LV 3 (2.4)
Other 7 (5.6)
UFT 5 (19.2) FOLFOX 3 (11.5)
Capecitabine 2 (7.7) CapeOX 1 (3.8)
FU + LV 1 (3.8)
Other 4 (15.4)
Number of pulmonary metastasectomy, n (%) 2 times 14 (53.9)
3 times 7 (26.9)
4 times 5 (19.2)
  1. ¶: Age at the initial pulmonary metastasectomy
  2. ✝: Brinkman index = (the number of cigarette smoked per day) × (the number of years of smoking)
  3. ‡: UICC TNM classification(the 8th edition)
  4. *p < 0.05; **p < 0.01; ***p < 0.001