Fig. 6

Immunohistochemical comparison between S100A10 and ANX A2 in case 2. I. a Positive reactions are seen not only in both PDCs (arrowheads) and tumor buds but also in the tumor cells protruding into the stroma. By contrast, the glandular components (asterisks) with a smooth border around the stroma show no or weak cytoplasmic positivity except for a reaction at the part of their luminal surface. S100A10 immunostain. Scale bar: 200 μm. b Magnified image of (a). Arrows and arrowheads indicate the protruding tumor cells and PDCs, respectively. The smooth border of glandular components is indicated by asterisks. S100A10 immunostain. Scale bar: 100 μm. c Image corresponds to (a). Immunolocalization for ANX A2 is basically similar to that for S100A10. ANX A2 immunostain. Scale bar: 200 μm. d Image corresponds to (b). ANX A2 immunostain. Scale bar: 100 μm