Table 3 Univariate and multivariate analyses of prognostic factors correlated with OS

Age (≥57 vs. <57)

1.051 (0.748-1.494)

0.754

Gender (Male vs. Female)

1.359 (0.948-1.948)

0.095

Tumor size (≥4cm vs. <4cm)

2.045 (1.442-2.901)

<0.001

1.724 (1.173-2.532)

0.006

Depth of invasion (T3/T4 vs. T1/T2)

3.095 (1.947-4.922)

<0.001

1.935 (1.198-3.128)

0.007

Lymph node metastasis (Positive vs. Negative)

3.885 (2.497-6.044)

<0.001

2.516 (1.585-3.993)

<0.001

TNM stage (III vs. I/II)

6.978 (4.694-10.373)

<0.001

5.077 (3.345-7.706)

<0.001

Differentiation (Low/undifferentiated vs. High/moderate)

0.898 (0.635-1.272)

0.546

Nerve invasion (Positive vs. Negative)

0.96 (0.671-1.375)

0.825

Vascular invasion (Positive vs. Negative)

1.678 (1.186-2.374)

0.003

1.328 (0.916-1.925)

0.134

FSTL1 expression (Positive vs. Negative)

3.041 (2.067-4.474)

<0.001

1.973 (1.284-3.031)

0.002