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Table 4 Results of univariable and multivariable analyses for disease-free survival

From: Predictors of survival after surgery with curative intent for perihilar cholangiocarcinoma

Parameter No. of patients Univariable Multivariable
p value Risk ratio (95% CI) p value
Patient-related
 Age   88 0.096 1.08 (0.22–5.60) 0.926
 Gender Male 52 0.617 1.10 (0.57–2.08) 0.771
Female 36    
 BMI   80 0.390   
 ASA > 2 29 0.864   
≤ 2 59    
 Year of diagnosis (10 years) 1998–2007 33 0.921   
2008–2017 55    
 Year of diagnosis (5 years) 1998–2002 14 0.256   
2003–2007 19    
2008–2012 30    
2013–2017 25    
 Cholangitis Yes 12 0.217   
No 76    
 Serum level of total bilirubin at presentation   88 0.288   
Tumour-related
 Pathological T-stage ≥ pT3 10 0.100 0.88 (0.29–2.41) 0.813
≤ pT2 78    
 Pathological N-stage pN+ 38 < 0.0001 2.95 (1.51–5.90) 0.002
pN0 46    
 Differentiation grading 1 20 0.275   
2 30    
3 14    
 Tumour size (mm)   69 0.510   
 ECLNI Yes 14 0.558   
No 25    
 Microvascular invasion Yes 59 0.507   
No 22    
 Macrovascular invasion Yes 20 0.021 3.11 (0.00–3.37) 0.273
No 68    
 Perineural invasion Yes 69 0.241   
No 17    
 R-status 1 14 0.455   
0 74    
 pRM ≤ 1 mm 36 0.002   
> 1 mm 14    
Surgery-related
 Intraoperative transfusion Yes 38 0.109   
No 50    
 Caudate lobe resection Yes 56 0.006 2.19 (1.01–5.14) 0.048
No 32    
 Major hepatectomy Yes 63 0.260   
No 25    
 Portal vein resection Yes 18 0.002 1.63 (0.50–2.01) 0.148
No 70    
  1. RR risk ratio, CI confidence interval, BMI body mass index, ASA American Society of Anesthesiologists physical status classification system, ECLNI extracapsular lymph node involvement, pRM magnitude of tumour-free resection margin, AJCC American Joint Committee on Cancer