From: Predictors of survival after surgery with curative intent for perihilar cholangiocarcinoma
Parameter | No. of patients | Univariable | Multivariable | ||
---|---|---|---|---|---|
p value | Risk ratio (95% CI) | p value | |||
Patient-related | |||||
 Age |  | 88 | 0.096 | 1.08 (0.22–5.60) | 0.926 |
 Gender | Male | 52 | 0.617 | 1.10 (0.57–2.08) | 0.771 |
Female | 36 | Â | Â | Â | |
 BMI |  | 80 | 0.390 |  |  |
 ASA | > 2 | 29 | 0.864 |  |  |
≤ 2 | 59 |  |  |  | |
 Year of diagnosis (10 years) | 1998–2007 | 33 | 0.921 |  |  |
2008–2017 | 55 |  |  |  | |
 Year of diagnosis (5 years) | 1998–2002 | 14 | 0.256 |  |  |
2003–2007 | 19 |  |  |  | |
2008–2012 | 30 |  |  |  | |
2013–2017 | 25 |  |  |  | |
 Cholangitis | Yes | 12 | 0.217 |  |  |
No | 76 | Â | Â | Â | |
 Serum level of total bilirubin at presentation |  | 88 | 0.288 |  |  |
Tumour-related | |||||
 Pathological T-stage | ≥ pT3 | 10 | 0.100 | 0.88 (0.29–2.41) | 0.813 |
≤ pT2 | 78 |  |  |  | |
 Pathological N-stage | pN+ | 38 | < 0.0001 | 2.95 (1.51–5.90) | 0.002 |
pN0 | 46 | Â | Â | Â | |
 Differentiation grading | 1 | 20 | 0.275 |  |  |
2 | 30 | Â | Â | Â | |
3 | 14 | Â | Â | Â | |
 Tumour size (mm) |  | 69 | 0.510 |  |  |
 ECLNI | Yes | 14 | 0.558 |  |  |
No | 25 | Â | Â | Â | |
 Microvascular invasion | Yes | 59 | 0.507 |  |  |
No | 22 | Â | Â | Â | |
 Macrovascular invasion | Yes | 20 | 0.021 | 3.11 (0.00–3.37) | 0.273 |
No | 68 | Â | Â | Â | |
 Perineural invasion | Yes | 69 | 0.241 |  |  |
No | 17 | Â | Â | Â | |
 R-status | 1 | 14 | 0.455 |  |  |
0 | 74 | Â | Â | Â | |
 pRM | ≤ 1 mm | 36 | 0.002 |  |  |
> 1 mm | 14 |  |  |  | |
Surgery-related | |||||
 Intraoperative transfusion | Yes | 38 | 0.109 |  |  |
No | 50 | Â | Â | Â | |
 Caudate lobe resection | Yes | 56 | 0.006 | 2.19 (1.01–5.14) | 0.048 |
No | 32 | Â | Â | Â | |
 Major hepatectomy | Yes | 63 | 0.260 |  |  |
No | 25 | Â | Â | Â | |
 Portal vein resection | Yes | 18 | 0.002 | 1.63 (0.50–2.01) | 0.148 |
No | 70 | Â | Â | Â |