Predictors of survival after surgery with curative intent for perihilar cholangiocarcinoma

Table 4 Results of univariable and multivariable analyses for disease-free survival

Parameter		No. of patients	Univariable	Multivariable
Parameter		No. of patients	p value	Risk ratio (95% CI)	p value
Patient-related
Age		88	0.096	1.08 (0.22–5.60)	0.926
Gender	Male	52	0.617	1.10 (0.57–2.08)	0.771
Gender	Female	36
BMI		80	0.390
ASA	> 2	29	0.864
ASA	≤ 2	59
Year of diagnosis (10 years)	1998–2007	33	0.921
Year of diagnosis (10 years)	2008–2017	55
Year of diagnosis (5 years)	1998–2002	14	0.256
	2003–2007	19
	2008–2012	30
	2013–2017	25
Cholangitis	Yes	12	0.217
Cholangitis	No	76
Serum level of total bilirubin at presentation		88	0.288
Tumour-related
Pathological T-stage	≥ pT3	10	0.100	0.88 (0.29–2.41)	0.813
Pathological T-stage	≤ pT2	78
Pathological N-stage	pN+	38	< 0.0001	2.95 (1.51–5.90)	0.002
Pathological N-stage	pN0	46
Differentiation grading	1	20	0.275
	2	30
	3	14
Tumour size (mm)		69	0.510
ECLNI	Yes	14	0.558
ECLNI	No	25
Microvascular invasion	Yes	59	0.507
Microvascular invasion	No	22
Macrovascular invasion	Yes	20	0.021	3.11 (0.00–3.37)	0.273
Macrovascular invasion	No	68
Perineural invasion	Yes	69	0.241
Perineural invasion	No	17
R-status	1	14	0.455
R-status	0	74
pRM	≤ 1 mm	36	0.002
pRM	> 1 mm	14
Surgery-related
Intraoperative transfusion	Yes	38	0.109
Intraoperative transfusion	No	50
Caudate lobe resection	Yes	56	0.006	2.19 (1.01–5.14)	0.048
Caudate lobe resection	No	32
Major hepatectomy	Yes	63	0.260
Major hepatectomy	No	25
Portal vein resection	Yes	18	0.002	1.63 (0.50–2.01)	0.148
Portal vein resection	No	70

RR risk ratio, CI confidence interval, BMI body mass index, ASA American Society of Anesthesiologists physical status classification system, ECLNI extracapsular lymph node involvement, pRM magnitude of tumour-free resection margin, AJCC American Joint Committee on Cancer

ISSN: 1477-7819