Predictors of survival after surgery with curative intent for perihilar cholangiocarcinoma

Table 3 Results of univariable and multivariable analyses for overall survival

Parameter		No. of patients	Univariable	Multivariable
Parameter		No. of patients	p value	Risk ratio (95% CI)	p value
Patient-related
Age		88	0.764	1.61 (0.36–7.91)	0.539
Gender	Male	52	0.583	1.21 (0.64–2.24)	0.555
Gender	Female	36
BMI		80	0.910
ASA	> 2	29	0.017	2.10 (1.03–4.25)	0.043
ASA	≤ 2	59
Year of diagnosis (10 years)	1998–2007	33	0.533
Year of diagnosis (10 years)	2008–2017	55
Year of diagnosis (5 years)	1998–2002	14	0.932
	2003–2007	19
	2008–2012	30
	2013–2017	25
Cholangitis	Yes	12	0.971
Cholangitis	No	76
Serum level of total bilirubin at presentation		88	0.098
Tumour-related
Pathological T-stage	> pT2	10	0.002	2.58 (1.03–6.30)	0.043
Pathological T-stage	≤ pT2	78
Pathological N-stage	pN+	38	< 0.002	2.12 (1.19–3.80)	0.011
Pathological N-stage	pN0	46
Differentiation grading	1	20	0.025
	2	30
	3	14
Tumour size (mm)		69	0.660
ECLNI	Yes	14	0.736
ECLNI	No	25
Microvascular invasion	Yes	59	0.769
Microvascular invasion	No	22
Macrovascular invasion	Yes	20	0.041	1.63 (0.09–8.27)	0.660
Macrovascular invasion	No	68
Perineural invasion	Yes	69	0.238
Perineural invasion	No	17
R-status	1	14	0.318
R-status	0	74
pRM	≤ 1 mm	36	0.127
pRM	> 1 mm	14
Surgery-related
Intraoperative transfusion	Yes	38	0.006	1.58 (0.89–2.83)	0.121
Intraoperative transfusion	No	50
Caudate lobe resection	Yes	56	0.111
Caudate lobe resection	No	32
Major hepatectomy	Yes	63	0.715
Major hepatectomy	No	25
Portal vein resection	Yes	18	0.020	0.78 (0.13–15.17)	0.828
Portal vein resection	No	70

RR risk ratio, CI confidence interval, BMI body mass index, ASA American Society of Anesthesiologists physical status classification system, ECLNI extracapsular lymph node involvement, pRM magnitude of tumour-free resection margin, AJCC American Joint Committee on Cancer

ISSN: 1477-7819