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Table 3 Results of univariable and multivariable analyses for overall survival

From: Predictors of survival after surgery with curative intent for perihilar cholangiocarcinoma

Parameter No. of patients Univariable Multivariable
p value Risk ratio (95% CI) p value
Patient-related
 Age   88 0.764 1.61 (0.36–7.91) 0.539
 Gender Male 52 0.583 1.21 (0.64–2.24) 0.555
Female 36    
 BMI   80 0.910   
 ASA > 2 29 0.017 2.10 (1.03–4.25) 0.043
≤ 2 59    
 Year of diagnosis (10 years) 1998–2007 33 0.533   
2008–2017 55    
 Year of diagnosis (5 years) 1998–2002 14 0.932   
2003–2007 19    
2008–2012 30    
2013–2017 25    
 Cholangitis Yes 12 0.971   
No 76    
 Serum level of total bilirubin at presentation   88 0.098   
Tumour-related
 Pathological T-stage > pT2 10 0.002 2.58 (1.03–6.30) 0.043
≤ pT2 78    
 Pathological N-stage pN+ 38 < 0.002 2.12 (1.19–3.80) 0.011
pN0 46    
 Differentiation grading 1 20 0.025   
2 30    
3 14    
 Tumour size (mm)   69 0.660   
 ECLNI Yes 14 0.736   
No 25    
 Microvascular invasion Yes 59 0.769   
No 22    
 Macrovascular invasion Yes 20 0.041 1.63 (0.09–8.27) 0.660
No 68    
 Perineural invasion Yes 69 0.238   
No 17    
 R-status 1 14 0.318   
0 74    
 pRM ≤ 1 mm 36 0.127   
> 1 mm 14    
Surgery-related
 Intraoperative transfusion Yes 38 0.006 1.58 (0.89–2.83) 0.121
No 50    
 Caudate lobe resection Yes 56 0.111   
No 32    
 Major hepatectomy Yes 63 0.715   
No 25    
 Portal vein resection Yes 18 0.020 0.78 (0.13–15.17) 0.828
No 70    
  1. RR risk ratio, CI confidence interval, BMI body mass index, ASA American Society of Anesthesiologists physical status classification system, ECLNI extracapsular lymph node involvement, pRM magnitude of tumour-free resection margin, AJCC American Joint Committee on Cancer