Variables | RFS | OS | ||
---|---|---|---|---|
HR (95%CI) | P value | HR (95%CI) | P value | |
Univariate analyses | ||||
Age (years) (> 60 vs. ≤ 60) | 0.670 (0.440, 1.018) | 0.061 | 0.794 (0.514, 1.226) | 0.298 |
Gender (male vs. female) | 0.899 (0.603, 1.341) | 0.603 | 0.763 (0.502, 1.161) | 0.207 |
Tumor size (cm) | 1.126 (1.053, 1.204) | 0.001 | 1.107 (1.035, 1.186) | 0.003 |
Number of tumors (multiple vs. single) | 1.797 (1.168, 2.763) | 0.008 | 1.936 (1.246, 3.008) | 0.003 |
AJCC tumor stage (III vs. I and II) | 1.726 (1.135, 2.624) | 0.011 | 1.960 (1.250, 3.074) | 0.003 |
Lymph node metastasis (yes vs. no) | 1.881 (1.243, 2.848) | 0.003 | 2.197 (1.430, 3.376) | < 0.001 |
Vascular invasion (yes vs. no) | 1.558 (1.041, 2.332) | 0.031 | 1.478 (0.972, 2.248) | 0.068 |
Tumor differentiation (poor to undifferentiated vs. well to moderate) | 2.173 (1.389, 3.401) | 0.001 | 1.971 (1.222, 3.179) | 0.005 |
ALT (U/L) | 0.998 (0.994, 1.001) | 0.195 | 0.999 (0.995, 1.003) | 0.570 |
AST (U/L) | 0.996 (0.990, 1.003) | 0.273 | 0.999 (0.993, 1.005) | 0.815 |
CEA (ng/ml) | 1.020 (1.008, 1.032) | 0.001 | 1.027 (1.015, 1.040) | < 0.001 |
CA19-9 (U/ml) | 1.002 (1.001, 1.002) | < 0.001 | 1.002 (1.001, 1.003) | < 0.001 |
CA242 (U/ml) | 1.005 (1.003, 1.007) | < 0.001 | 1.005 (1.003, 1.007) | < 0.001 |
NLR | 1.018 (0.947, 1.096) | 0.625 | 1.033 (0.960, 1.112) | 0.387 |
PLR | 1.003 (1.000, 1.005) | 0.021 | 1.003 (1.001, 1.006) | 0.011 |
LMR | 1.039 (0.943, 1.146) | 0.435 | 1.019 (0.903, 1.151) | 0.757 |
SII (SII-low group vs. SII-high group) | 2.352 (1.519, 3.641) | < 0.001 | 2.340 (1.484, 3.689) | < 0.001 |
Albumin (g/L) | 0.979 (0.936, 1.023) | 0.347 | 0.969 (0.924, 1.017) | 0.203 |
Child-Pugh score (B vs. A) | 0.996 (0.564, 1.757) | 0.988 | 1.286 (0.725, 2.279) | 0.389 |
Multivariate analyses | ||||
Tumor size (cm) | 1.030 (0.953, 1.113) | 0.456 | 0.976 (0.899, 1.060) | 0.563 |
Number of tumors (multiple vs. single) | 1.849 (1.168, 2.928) | 0.009 | 2.017 (1.274, 3.192) | 0.003 |
AJCC tumor stage (III vs. I and II) | 1.599 (1.018, 2.511) | 0.042 | 1.982 (1.207, 3.255) | 0.007 |
Tumor differentiation (poor to undifferentiated vs. well to moderate) | 2.355 (1.444, 3.840) | 0.001 | 1.865 (1.093, 3.182) | 0.022 |
CEA (ng/ml) | 1.022 (1.008, 1.037) | 0.003 | 1.033 (1.017, 1.049) | < 0.001 |
CA19-9 (U/ml) | 1.001 (1.000, 1.002) | 0.034 | 1.002 (1.001, 1.003) | 0.001 |
CA242 (U/ml) | 1.001 (0.998, 1.004) | 0.552 | 0.999 (0.996, 1.003) | 0.712 |
PLR | 0.998 (0.995, 1.002) | 0.327 | 0.998 (0.995, 1.002) | 0.316 |
SII (SII-high group vs. SII-low group) | 2.368 (1.279, 4.386) | 0.006 | 2.454 (1.278, 4.712) | 0.007 |