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Table 1 Demographics and quality assessments of included studies

From: Laparoscopic procedure is associated with lower morbidity for simultaneous resection of colorectal cancer and liver metastases: an updated meta-analysis

Study, year

Country

Study

period

Study

design

Criteria

Matched factorsb

No. of participants (MH, %)

Age, Mean (SD), y

Female, No. (%)

Quality

score

Inclusion

Exclusiona

Lap

Open

Lap

Open

Lap

Open

Ma et al. [23], 2018

China

2014–2017

PSM (R, S)

Primary CRC and SCRLM

1–3

1–3, 5, 7, 11, 12, 15–17, 21, 22,24–26

12 (25)

12 (33)

3c (25)

1c (8)

3 (25)

4 (33)

8

Ivanecz et al [20], .2018

Slovenia

2000–2016

PSM (P, S)

Primary CRC and SCRLM

4–6

1–3, 5, 7, 10–12, 15, 20–27

10 (0)

10 (0)

62 (8)

65 (8)

4 (40)

4 (40)

8

Xu et al. [26], 2017

China

2009–2014

PSM (R, S)

Primary CRC and SCRLM

5, 7

1–3, 5–7, 9, 10, 12, 15–17, 20–22,24– 26, 28

20 (25)

20 (20)

58 (11)

60 (11)

7 (35)

6 (30)

8

Chen et al [16], .2018

Taiwan, China

2009–2017

NM (R, S)

Primary CRC and SCRLM

2, 6, 8–11

1, 2, 7, 11–13, 15, 17, 20, 21, 24, 25, 28, 29

16 (19)

22 (14)

66 (10)

65 (13)

6 (38)

13 (59)

6

Gorgun et al [17], .2017

USA

2006–2015

NM (P, S)

Primary CRC and SCRLM

NR

1, 2, 3, 7, 9–12, 15, 16, 18, 21, 22,24– 26, 28, 29

14 (14)

29 (14)

56 (3)

58 (3)

8 (57)

13 (45)

6

Ratti et al [24], .2016

Italy

2004–2015

PSM (P, S)

Primary CRC and SCRLM

4, 12, 13

1–3, 5, 10, 12, 16– 18, 20–22, 24–26, 28, 29

25 (24)

50 (20)

60 (11)

61 (10)

11 (44)

23 (46)

8

Tranchart et al [25], .2016

France

1997–2013

PSM (R, M)

Liver lesions ≤ 5 cm with segments II– VI

14

1, 2, 7, 10–12, 14, 16, 20, 21,24–26, 28,29

89 (8)

89 (6)

67 (11)

65 (9)

47 (53)

49 (55)

8

Lin et al [22], .2015

China

2008–2012

PSM (P, S)

Primary CRC and SCRLM

15–18

1–3, 5, 7–16, 20, 21, 24–26, 28

7 (0)

36 (17)

60 (3)

57 (10)

2 (29)

15 (58)

8

Jung et al [21], .2013

Korea

2008–2012

CM (P, S)

Primary CRC and SCRLM

5, 19

1, 2, 7, 9–12, 16, 19– 21, 24, 25, 27, 28

24 (25)

24 (25)

60 (43–75)

60 (37–80)

11 (46)

7 (29)

6

Hu et al. [18], 2012

China

2004–2008

CM (R, M)

Metastasis restricted to the left lobe or a segment in the right lobe with size < 6 cm

6, 20, 21, 22

1, 2, 7, 8, 10, 11, 15, 17–19, 28

13 (15)

13 (15)

54 (10)

53 (11)

3 (23)

4 (31)

8

Huh et al [19], .2011

Korea

2003–2008

CM (P, S)

Primary CRC and SCRLM

NR

1–3, 5, 7, 9–16, 25, 28

20d (NR)

20 (NR)

63 (36– 71)

62 (44–85)

7 (35)

5 (25)

8

Chen et al [15], .2011

China

1999–2005

CM (R, S)

Rectal tumor fit for Dixon’s surgery and the number of liver lesions ≤ 2

21, 23, 24

1–10, 13–16

23 (26)

18 (NR)

55 (10)

53 (9)

5 (22)

4 (22)

8

  1. CRC Colorectal cancer, SCRLM Synchronous liver metastases, CM Case-matched, PSM Propensity score matching, MH Major hepatectomy (≥ 3 segments), P prospectively collected data, R retrospectively collected data, M multicenters, S single center, NR not report
  2. aExclusion criteria are defined as follows: (1) loss to follow-up; (2) with other malignant tumors; (3) combined multiple organ resection;(4) two stage approaches (colorectal first or liver first; (5) combined radiofrequency ablation; (6) extrahepatic metastases; (7) the application of mixed approaches, initially unresectable SCRLM; (8) with hepatic cellular cancer; (9) with neuroendocrine tumor; (10) with benign liver tumor; (11) with peritoneum seeding; (12) mixed approach (laparoscopic colorectal resection and open hepatectomy or vice versa); (13) follow-up< 12 months; (14) tumors close to the portal pedicle or hepatic veins; (15) incomplete material; (16) with obstructive colorectal cancer; (17) with cancer perforation; (18) with T4 colorectal cancer; (19) minor procedures performed by colorectal surgeon only(liver biopsy or wedge resection of synchronous liver metastases in the liver edge); (20) liver metastasis located in the right hemiliver at a size of > 6cm or requiring the resection of > 2 segments; (21) with a previous history of abdominal surgery or tuberculous peritonitis; (22) with serious cardiopulmonary insufficiency; (23)the rectal tumor fit for Mile’s surgery; (24) the number of liver lesions ≥ 3
  3. bMatched factors means the covariate was matched or the difference of the covariate was not statistically significant between two groups and are defined as follows: (1) age; (2) sex; (3) carcinoembryonic antigen; (4) distance between rectal tumors and anus; (5) tumor differentiation; (6) child class; (7) liver metastases size; (8) location of liver metastases (segments 1, 2 ,3, 4b, 4a, 5 ,6, 7, 8); (9) primary tumor size; (10) location of primary tumor (colon/rectum); (11) body mass index; (12) American Society of Anesthesiologists; (13) lymphovascular invasion; (14) depth of primary tumor invasion; (15) postoperative chemotherapy; (16) distribution of metastases (unilobar/bilobar); (17) primary tumor stage; (18) comorbid disease; (19) previous abdomen surgery; (20) types of colorectal and hepatic surgery; (21) number of liver metastases; (22) preoperative chemotherapy; (23) location of liver metastases (anterolateral/posterosuperior); (24) primary tumor T stage; (25) primary nodal status; (26) neoadjuvant chemotherapy; (27) harvested lymph nodes; (28) the type of hepatoenterectomy; (29) recurrence
  4. cThe number (%) of patients > 60 years
  5. dSeven of the 20 patients underwent a total one-step laparoscopic procedure while 13 patients underwent laparoscopic colorectal resection and open liver resection
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World Journal of Surgical Oncology

ISSN: 1477-7819

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