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Table 4 Disease-free survival analysis by clinicopathologic variables and body composition factors

From: Prognostic role of pre-sarcopenia and body composition with long-term outcomes in obstructive colorectal cancer: a retrospective cohort study

Variable Analysis
Univariate Multivariable
HR [95% CI] P value HR [95% CI] P value
Sex, male 1.09 [0.63–1.88] 0.818
Age > 60 1.03 [0.60–1.78] 0.908   
ASA (I vs II + III + IV) 1.08 [0.60–1.94] 0.790
Stage (II vs III) 6.27 [2.13–17.39] < 0.001 3.64 [1.14–11.67] 0.030
Vascular invasion 2.05 [1.09–3.84] 0.026 1.77 [0.92–3.37] 0.087
Lymphatic invasion 3.81 [1.72–8.44] 0.001 1.76 [0.70–4.43] 0.229
Pre-operative CEA level > 5 2.17 [1.25–3.75] 0.006 2.226 [1.28–3.87] 0.005
Neutrophil lymphocyte ratio ≥ 5 0.31 [0.35–1.34] 0.702   
Differentiation (well vs moderate +poor) 1.70 [0.41–7.01] 0.461
BMI ≥ 25 0.69 [0.36–1.35] 0.265
Visceral obesity ≥ 130[33] 0.65 [0.34–1.27] 0.206
Subcutaneous fat area (cm2) > 92a 0.80 [0.47–1.37] 0.417
Abdominal circumference (cm) > 83a 0.89 [0.52–1.52] 0.663
CONUT score > 7[22] 0.91 [0.22–3.79] 0.892
Pre-sarcopenia, men < 46.4 cm2, women < 37.5 cm2 [32] 1.83 [1.08–3.22] 0.023 1.86 [1.04-3.13] 0.037
  1. CI confidence interval, ASA American Society of Anesthesiologist physical status, CEA carcinoembryonic antigen, BMI body mass index, CONUT Controlling Nutritional Status
  2. aMedian value