|
Primary outcomes
|
|
Complication
|
Overall postoperative complication
|
10
|
804
|
983
|
0.65 (0.46, 0.90)
|
0.01
|
5.0
|
0.40
|
|
Incision related complication
|
8
|
652
|
848
|
0.13 (0.05, 0.35)
|
< 0.01
|
0
|
0.98
|
|
Anastomotic fistula
|
8
|
647
|
847
|
1.09 (0.61, 1.96)
|
0.78
|
0
|
0.81
|
|
Severe complication
|
2
|
157
|
136
|
0.22 (0.01, 3.66)
|
0.29
|
74.1
|
0.05
|
|
Pathologic outcomes
|
Lymph nodes harvested
|
9
|
682
|
885
|
− 0.52 (− 1.09, 0.05)
|
0.07
|
0
|
0.64
|
|
Proximal resection margin
|
3
|
150
|
190
|
0.21 (− 0.73, 1.14)
|
0.67
|
0
|
0.82
|
|
Distal resection edge
|
4
|
215
|
322
|
0.17 (0.02, 0.33)
|
0.02
|
0
|
0.40
|
|
Secondary outcomes
|
|
Operation time
|
9
|
682
|
885
|
7.40 (0.17, 14.64)
|
0.04
|
69.9
|
< 0.01
|
|
Intraoperative blood loss
|
9
|
682
|
885
|
− 10.25 (− 23.22, 2.73)
|
0.12
|
89.7
|
< 0.01
|
|
Recovery of gastrointestinal function
|
6
|
545
|
691
|
− 0.38 (− 0.70, − 0.06)
|
0.02
|
89.6
|
< 0.01
|
|
Postoperative pain (POD 1)
|
4
|
159
|
242
|
− 1.64 (− 2.31, − 0.98)
|
< 0.01
|
84.7
|
< 0.01
|
|
Additional analgesics usage
|
4
|
159
|
242
|
0.21 (0.11, 0.40)
|
< 0.01
|
0
|
0.56
|
|
Hospital stay
|
9
|
682
|
885
|
− 0.71 (− 1.10, − 0.32)
|
< 0.01
|
52.5
|
0.03
|
|
Five-year OS
|
2
|
174
|
150
|
0.69 (0.19, 2.45)
|
0.56
|
0
|
0.92
|
|
Five-year DFS
|
2
|
174
|
150
|
0.83 (0.41, 1.66)
|
0.59
|
0
|
0.55
|
