Table 2 The pooled results of all outcomes
Outcomes | No. of studies | No. of patients | Pooled results WMD or OR (95%CI) | P value | Heterogeneity | |||
|---|---|---|---|---|---|---|---|---|
NOSE-LAR | AISE-LAR | I2 (%) | P value | |||||
Primary outcomes | ||||||||
Complication | Overall postoperative complication | 10 | 804 | 983 | 0.65 (0.46, 0.90) | 0.01 | 5.0 | 0.40 |
Incision related complication | 8 | 652 | 848 | 0.13 (0.05, 0.35) | < 0.01 | 0 | 0.98 | |
Anastomotic fistula | 8 | 647 | 847 | 1.09 (0.61, 1.96) | 0.78 | 0 | 0.81 | |
Severe complication | 2 | 157 | 136 | 0.22 (0.01, 3.66) | 0.29 | 74.1 | 0.05 | |
Pathologic outcomes | Lymph nodes harvested | 9 | 682 | 885 | − 0.52 (− 1.09, 0.05) | 0.07 | 0 | 0.64 |
Proximal resection margin | 3 | 150 | 190 | 0.21 (− 0.73, 1.14) | 0.67 | 0 | 0.82 | |
Distal resection edge | 4 | 215 | 322 | 0.17 (0.02, 0.33) | 0.02 | 0 | 0.40 | |
Secondary outcomes | ||||||||
Operation time | 9 | 682 | 885 | 7.40 (0.17, 14.64) | 0.04 | 69.9 | < 0.01 | |
Intraoperative blood loss | 9 | 682 | 885 | − 10.25 (− 23.22, 2.73) | 0.12 | 89.7 | < 0.01 | |
Recovery of gastrointestinal function | 6 | 545 | 691 | − 0.38 (− 0.70, − 0.06) | 0.02 | 89.6 | < 0.01 | |
Postoperative pain (POD 1) | 4 | 159 | 242 | − 1.64 (− 2.31, − 0.98) | < 0.01 | 84.7 | < 0.01 | |
Additional analgesics usage | 4 | 159 | 242 | 0.21 (0.11, 0.40) | < 0.01 | 0 | 0.56 | |
Hospital stay | 9 | 682 | 885 | − 0.71 (− 1.10, − 0.32) | < 0.01 | 52.5 | 0.03 | |
Five-year OS | 2 | 174 | 150 | 0.69 (0.19, 2.45) | 0.56 | 0 | 0.92 | |
Five-year DFS | 2 | 174 | 150 | 0.83 (0.41, 1.66) | 0.59 | 0 | 0.55 | |