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Table 4 Cox regression analysis evaluating the value of surgical margins and perineural invasion as a predictor of time to biochemical recurrence in a subgroup analysis regarding pathological tumor stage

From: Impact of positive surgical margin location and perineural invasion on biochemical recurrence in patients undergoing radical prostatectomy

Variable pT2 (n = 270) pT3 (n = 146)
Univariable Multivariable1 Univariable Multivariable1
HR (95% CI) p value HR (95% CI) p value HR (95% CI) p value HR (95% CI) p value
Surgical margins   < 0.001   0.002   < 0.001   0.011
 NSM 1.0 (Ref.)   1.0 (Ref.)   1.0 (Ref.)   1.0 (Ref.)  
 AM 4.8 (2.1–11.2) < 0.001 4.9 (2.1–11.8) < 0.001 2.3 (0.8–6.5) 0.122 3.7 (1.2–11.1) 0.019
 OM 2.1 (0.5–9.1) 0.343 2.6 (0.6–11.5) 0.216 2.6 (1.3–5.3) 0.007 1.3 (0.6–2.6) 0.51
 MM 6.5 (3.0–14.5) < 0.001 3.1 (1.3–7.5) 0.014 4.5 (2.2–9.2) < 0.001 2.8 (1.4–5.9) 0.005
Perineural invasion
 No 1.0 (Ref.)     1.0 (Ref.)   1.0 (Ref.)  
 Yes 2.4 (1.2–4.6) 0.01 0.9 (0.4–2.0) 0.808 1.7 (1.0–2.9) 0.044 1.5 (0.9–2.6) 0.157
  1. 1Adjusted for BMI, TPSA, and Gleason Score