Different surgical outcome and follow-up status between dMMR and pMMR colorectal cancer patients who fulfilled with Amsterdam-II criteria

Table 3 Univariate and multivariate analyses of disease-free survival (DFS) related to clinical variables

Characteristics	N	DFS (%)			p value	Multiple Cox
Characteristics	N	1 year	3 years	5 years	p value	HR	95% C.I.	p
HNHPCC					< 0.001
pMMR	51	84.00	67.94	63.40		1
dMMR	110	96.25	94.37	93.42		0.28	(0.108~0.733)	0.009
Sex					0.147
F	86	95.18	89.14	86.65
M	75	89.13	82.27	0.00
Operation type					0.029
Hemicolectomy	111	88.75	80.24	78.27		1
Sub/total colectomy	50	100.00	98.00	96.00		0.41	(0.113~1.523)	0.185
Tumor location					< 0.001
Right colon	82	97.48	93.67	93.67		1
Left colon	48	89.58	85.42	81.14		1.93	(0.601~6.212)	0.269
Rectum	31	82.76	65.52	62.07		1.97	(0.581~6.663)	0.276
Tumor histology					0.522
Adenocarcinoma	134	92.34	85.41	83.03
Mucinous/signet ring	23	95.45	90.91	90.91
Unclassified	4	75.00	75.00	75.00
Tumor differentiation					0.360
Well	29	100.00	96.55	92.69
Moderate	100	89.75	82.52	80.41
Poor	29	92.86	85.71	85.71
TNM_T stage					0.678
1	13	100.00	92.31	92.31		1
2	14	92.86	92.86	92.86		0.58	(0.052~6.567)	0.662
3	82	91.22	83.61	79.67		0.75	(0.147~3.786)	0.724
4	52	92.00	86.00	86.00		0.86	(0.154~4.773)	0.861
TNM_N stage					< 0.001
0	111	98.13	92.52	91.54		1
1	33	93.84	90.61	87.25		1.10	(0.314~3.873)	0.879
2	16	50.00	37.50	31.25		11.22	(4.015~31.343)	< 0.001
3	1	100.00	–	–		125.71	(9.975~1584.441)	< 0.001

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