Loss of survival advantage for deficient mismatch repair in patients with advanced colorectal cancer may be caused by changes in prognostic value of CD8+T cell

Table 2 Univariate and multivariate survival analysis for risk factors for overall survival and disease-free survival

	Univariate for OS	Multivariate for OS		Univariate for DFS	Multivariate for DFS
Factors	P	HR (95% CI)	P	P	HR (95% CI)	P
CT-CD3(H/L)	0.005	0.026 (0.050–0.685)	0.012	0.006	0.217 (0.067–0.700)	0.011
IM-CD3(H/L)	0.091	0.242 (0.065–0.899)	0.034	0.027	0.188 (0.058–0.617)	0.006
CT-CD4(H/L)	0.069	—	0.261	0.192	—	0.222
IM-CD4(H/L)	0.002	0.029 (0.005–0.187)	0.001	0.011	0.077 (0.018–0.329)	0.001
CT-CD8(H/L)	0.114	—	0.320	0.083	—	0.274
IM-CD8(H/L)	0.770	—	0.847	0.795	—	0.452
IS(H/L)	0.005	—	0.121	0.007	0.098 (0.013–0.755)	0.026
CT-PD-L1 (+/−)	0.382	—	0.439	0.245	—	0.375
IM-PD-L1 (+/−)	0.688	—	0.711	0.233	—	0.497

OS overall survival, DFS disease-free survival, HR hazard ratio, CT center of tumor, IM invasive margin, IS immunoscore

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