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Table 2 Subgroup analyses for the association between LMR and OS in PC

From: Prognostic value of lymphocyte to monocyte ratio in pancreatic cancer: a systematic review and meta-analysis including 3338 patients

Subgroup No of studies No of patients Effects model HR (95% CI) P value Heterogeneity
I2 (%) Ph
Overall 16 3338 Random 0.68 (0.58–0.80) < 0.001 69.3 < 0.001
Ethnicity        
 Asian 13 2325 Random 0.66 (0.53–0.82) < 0.001 72.0 < 0.001
 Caucasian 2 916 Random 0.75 (0.59–0.96) 0.025 26.3 0.244
Study design        
 Prospective 8 1858 Random 0.73 (0.65–0.83) < 0.001 25.5 0.226
 Retrospective 8 1480 Random 0.64 (0.45–0.92) 0.015 81.7 < 0.001
Treatment        
 Surgery 5 1146 Random 0.55 (0.30–0.99) 0.049 87.1 < 0.001
 Chemotherapy 8 1554 Random 0.71 (0.61–0.83) < 0.001 31.8 0.174
 Mixed 3 638 Random 0.81 (0.72–0.92) 0.001 0 0.712
Variable type        
 Univariate 4 629 Random 0.81 (0.70–0.93) 0.004 0 0.829
 Multivariate 12 2709 Random 0.65 (0.52–0.81) < 0.001 75.5 < 0.001
Cut-off for LMR        
 ≤ 3 11 2560 Random 0.67 (0.54–0.84) < 0.001 78.2 < 0.001
 > 3 5 778 Random 0.68 (0.57–0.81) < 0.001 0 0.697
Tumor stage        
 I–III 3 915 Random 0.43 (0.16–1.11) 0.081 92.5 < 0.001
 III–IV 9 1621 Random 0.70 (0.60–0.81) < 0.001 22.8 0.241
 I–IV 3 707 Random 0.82 (0.72–0.92) 0.001 0 0.878