Variable | No. of studies | No. of patients | Effects model | OR (95% CI) | p | Heterogeneity | |
---|---|---|---|---|---|---|---|
I2 | Ph | ||||||
Tumor differentiation (moderate/high vs. poor) | 18 | 6721 | Fixed | 1.04 (0.98–1.11) | 0.173 | 7.30% | 0.367 |
Tumor location (cardia vs. non-cardia) | 10 | 2905 | Fixed | 0.99 (0.87–1.12) | 0.837 | 6.00% | 0.386 |
Tumor size (≤ 5 vs. > 5 cm) | 8 | 2596 | Random | 1.04 (0.88–1.23) | 0.634 | 74.20% | < 0.001 |
Lymph node metastasis (no vs. yes) | 15 | 6752 | Random | 1.17 (1.02–1.33) | 0.023 | 71.90% | < 0.001 |
Depth of invasion (T1–T2 vs. T3–T4 ) | 13 | 6250 | Random | 1.34 (1.10–1.64) | 0.003 | 86.20% | < 0.001 |
TNM (Tis-II vs. III-IV) | 16 | 6834 | Random | 1.20 (1.06–1.37) | 0.004 | 77.30% | < 0.001 |