| Factors | No. of studies | No. of patients | Effects model | HR (95% CI) | p | Heterogeneity | |
---|---|---|---|---|---|---|---|---|
I2 | Ph | |||||||
OS | Overall | 44 | 26901 | Random | 1.37 (1.26–1.49) | < 0.001 | 79.90% | < 0.001 |
 | Ethnicity | |||||||
 |  Caucasian | 9 | 1981 | Random | 1.31 (0.96–1.79) | 0.092 | 84.10% | < 0.001 |
 |  Asian | 35 | 24920 | Random | 1.39 (1.28–1.52) | < 0.001 | 79.20% | < 0.001 |
 | Treatment | |||||||
 |  Chemotherapy | 7 | 967 | Random | 1.34 (0.96–1.88) | 0.084 | 76.10% | < 0.001 |
 |  Surgery | 31 | 24128 | Random | 1.39 (1.26–1.52) | < 0.001 | 79.10% | < 0.001 |
 |  Mixed | 6 | 1806 | Random | 1.38 (0.98–1.93) | 0.062 | 88.20% | < 0.001 |
 | Cut-off | |||||||
 |  ≤ 150 | 20 | 15181 | Random | 1.36 (1.20–1.54) | < 0.001 | 75.00% | < 0.001 |
 |  > 150 | 23 | 10357 | Random | 1.42 (1.24–1.63) | < 0.001 | 78.50% | < 0.001 |
 | Sample size | |||||||
 |  ≤ 500 | 29 | 6924 | Random | 1.42 (1.24–1.64) | < 0.001 | 75.70% | < 0.001 |
 |  > 500 | 15 | 19977 | Random | 1.34 (1.20–1.50) | < 0.001 | 85.00% | < 0.001 |
DFS | Overall | 10 | 5354 | Random | 1.52 (1.22–1.90) | < 0.001 | 88.60% | < 0.001 |