| |
Factors
|
No. of studies
|
No. of patients
|
Effects model
|
HR (95% CI)
|
p
|
Heterogeneity
|
|---|
|
I2
|
Ph
|
|---|
|
OS
|
Overall
|
44
|
26901
|
Random
|
1.37 (1.26–1.49)
|
< 0.001
|
79.90%
|
< 0.001
|
| |
Ethnicity
|
| |
Caucasian
|
9
|
1981
|
Random
|
1.31 (0.96–1.79)
|
0.092
|
84.10%
|
< 0.001
|
| |
Asian
|
35
|
24920
|
Random
|
1.39 (1.28–1.52)
|
< 0.001
|
79.20%
|
< 0.001
|
| |
Treatment
|
| |
Chemotherapy
|
7
|
967
|
Random
|
1.34 (0.96–1.88)
|
0.084
|
76.10%
|
< 0.001
|
| |
Surgery
|
31
|
24128
|
Random
|
1.39 (1.26–1.52)
|
< 0.001
|
79.10%
|
< 0.001
|
| |
Mixed
|
6
|
1806
|
Random
|
1.38 (0.98–1.93)
|
0.062
|
88.20%
|
< 0.001
|
| |
Cut-off
|
| |
≤ 150
|
20
|
15181
|
Random
|
1.36 (1.20–1.54)
|
< 0.001
|
75.00%
|
< 0.001
|
| |
> 150
|
23
|
10357
|
Random
|
1.42 (1.24–1.63)
|
< 0.001
|
78.50%
|
< 0.001
|
| |
Sample size
|
| |
≤ 500
|
29
|
6924
|
Random
|
1.42 (1.24–1.64)
|
< 0.001
|
75.70%
|
< 0.001
|
| |
> 500
|
15
|
19977
|
Random
|
1.34 (1.20–1.50)
|
< 0.001
|
85.00%
|
< 0.001
|
|
DFS
|
Overall
|
10
|
5354
|
Random
|
1.52 (1.22–1.90)
|
< 0.001
|
88.60%
|
< 0.001
|
- HR hazard ratio, 95% CI 95% confidence interval, Php values of Q test for heterogeneity test, OS overall survival, DFS disease-free survival
