Rapid exacerbation featuring acute leukemoid reaction after retrolaparoscopic nephrectomy: a rare case report of renal cell carcinoma with postoperative comprehensive genomic profiling

Table 1 Outcomes of postoperative tissue-originated comprehensive genomic profiling

Genes	Mutation types	Mutation sites	Mutation abundance
Genes	Mutation types	Mutation sites	1st operation	2nd operation
PIK3CA	missense mutation	exon21	3.73%	13.46%
EGFR	gene amplification	—	8.86 copies	30.33 copies
NOTCH1	missense mutation	exon6	1.27%	6.15%
FAT4	missense mutation	exon1	13.26%	16.89%
STAG2	frameshift mutation	exon26	17.66%	27.51%
ATR	missense mutation	exon13	42.68%	42.34%
PRKDC	nonsense mutation	exon77	43.48%	48.69%

PIK3CA phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha; EGFR epidermal growth factor receptor; NOCTH1 notch homolog 1; FAT4 FAT atypical cadherin 4; STAG2 stromal antigen 2; ATR ataxia telangiectasia and Rad3 serine/threonine kinase; PRKDC protein kinase, DNA-activated, catalytic subunit

ISSN: 1477-7819