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Table 1 Outcomes of postoperative tissue-originated comprehensive genomic profiling

From: Rapid exacerbation featuring acute leukemoid reaction after retrolaparoscopic nephrectomy: a rare case report of renal cell carcinoma with postoperative comprehensive genomic profiling

Genes Mutation types Mutation sites Mutation abundance
1st operation 2nd operation
PIK3CA missense mutation exon21 3.73% 13.46%
EGFR gene amplification 8.86 copies 30.33 copies
NOTCH1 missense mutation exon6 1.27% 6.15%
FAT4 missense mutation exon1 13.26% 16.89%
STAG2 frameshift mutation exon26 17.66% 27.51%
ATR missense mutation exon13 42.68% 42.34%
PRKDC nonsense mutation exon77 43.48% 48.69%
  1. PIK3CA phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha; EGFR epidermal growth factor receptor; NOCTH1 notch homolog 1; FAT4 FAT atypical cadherin 4; STAG2 stromal antigen 2; ATR ataxia telangiectasia and Rad3 serine/threonine kinase; PRKDC protein kinase, DNA-activated, catalytic subunit