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Table 2 Univariate and multivariate Cox regression of clinicopathological for overall survival

From: Comparison of non-schistosomal colorectal cancer and schistosomal colorectal cancer

Variable All patients Patients with stage I–II disease Patients with stage III–IV disease Patients with LNM Patients without LNM
P HR (95% CI) P HR (95% CI) P HR (95% CI) P HR (95% CI) P HR (95% CI)
Univariate analysis
 Age (< 60 years) 0.010 1.759 (1.142–2.708) 0.009 3.413 (1.355–8.597) 0.244 1.343 (0.818–2.205) 0.116 1.533 (0.900–2.611) 0.024 0.424 (0.201–0.894)
 Gender (male/female) 0.008 1.602 (1.129–2.271) 0.046 1.897 (1.010–3.564) 0.018 1.670 (1.093–2.553) 0.020 1.714 (1.089–2.697) 0.103 1.584 (0.912–2.752)
 Tumor size (5 cm) 0.913 1.018 (0.728–1.400) 0.735 0.909 (0.523–1.580) 0.480 1.157 (0.772–1.735) 0.233 1.297 (0.846–1.987) 0.435 0.816 (0.491–1.358)
 Tumor site
  Rectum   Refer   Refer   Refer   Refer Refer  
  Left colon 0.908 1.025 (0.676–1.553) 0.670 1.168 (0.572–2.385) 0.926 0.975 (0.572–1.663) 0.926 0.975 (0.572–1.663) 0.942 1.025 (0.527–1.995)
  Right colon 0.464 0.859 (0.572–1.290) 0.860 0.939 (0.467–1.888) 0.249 0.728 (0.425–1.249) 0.249 0.728 (0.425–1.249) 0.967 1.013 (0.531–1.865)
 Pathological T stage < 0.001 2.591 (1.562–4.297) 0.633 1.158 (0.634–2.116) 0.007 6.803 (1.675–27.633) 0.010 6.323 (1.554–25.722) 0.275 1.385 (0.541–1.486)
 Lymph node metastasis < 0.001 2.802 (2.012–3.902) 0.041 4.410 (1.063–18.289) 0.558 0.828 (0.441–1.556)
 TNM stage < 0.001 3.197 (2.271–4.501) 0.827 0.855 (0.210–3.481) < 0.001 4.275 (2.203–8.298)
 Differentiation < 0.001 1.889 (1.334–2.674) 0.833 1.084 (0.510–2.307) 0.019 1.083 (1.083–2.466) 0.126 1.407 (0.909–2.177) 0.074 1.742 (0.957–3.169)
 Lymphovascular invasion < 0.001 3.251 (1.987–5.318) 0.163 1.538 (0.840–2.815) 0.011 1.702 (1.132–2.559) 0.019 1.670 (1.088–2.561) 0.036 1.782(1.039-3.056)
 Nervous invasion 0.140 1.497 (0.876–2.559) 0.281 1.759 (0.630–4.909) 0. 866 1.056 (0.562–1.985) 0.943 0.976 (0.503–1.893) 0.176 1.888 (0.752–4.741)
 Lymph nodes positive for CRC < 0.001 4.006 (2.686–5.973) 0.007 16.949 (2.188–131.284) < 0.001 2.178 (1.410–3.366) < 0.001 0.723 (1.479–3.693) 0.001 5.338 (1.907–14.943)
 Colonic perforation 0.541 0.700 (0.223–2.198) 0.824 1.174 (0.285–4.829) 0.768 0.809 (0.198–3.303) 0.461 0.475 (0.066–3.428) 0.512 1.475 (0.462–4.711)
 Tumor budding < 0.001 2.028 (1.400–2.938) 0.043 1.812 (1.019–3.221) 0.163 1.423 (0.867–2.336) 0.234 0.723 (0.424–1.232) 0.023 1.849 (1.087–3.146)
 Schistosomiasis 0.044 1.399 (1.009–1.940) 0.474 1.225 (0.703–2.132) 0.011 1.699 (1.128–2.560) 0.019 1.674 (1.087–2.577) 0.428 1.229 (0.738–2.049)
 Ulceration 0.624 0.9205 (0.660–1.282) 0.362 0.766 (0.4313–1.360) 0.971 1.008 (0.670–1.514) 0.649 1.104 (0.721–1.690) 0.189 0.698 (0.408–1.194)
 Histological type 0.921 1.025 (0.626–1.680) 0.797 0.886 (0.352–2.230) 0.870 0.952 (0.529–1.713) 0.708 0.889 (0.482–1.641) 0.902 0.948 (0.408–2.206)
Multivariate analysis
 Gender 0.003 1.676 (1.178–2.384) 0.030 1.601 (1.047–2.450) 0.026 1.675 (1.064–2.639)
 Pathological T stage 0.012 6.042 (1.476–24.729) 0.025 5.040 (1.228–20.678)
 TNM stage < 0.001 0.389 (0.267–0.567) < 0.001 4.507 (2.303–8.818)
 Lymph node metastasis         
 Tumor budding        0.014 0.513 (0.301–0.876)
 Differentiation 0.016 1.677 (1.101–2.555)     
 Schistosomiasis 0.025 1.458 (1.049–2.027) 0.008 1.743 (1.153–2.635) 0.023 1.648 (1.070–2.538)
 Lymphovascular invasion 0.030 1.461 (1.036–2.060)
 Lymph nodes positive for CRC < 0.001 2.256 (1.461–3.483) 0.007 16.8587 (2.176–130.580) 0.004 1.911 (1.230–2.969) 0.003 2.005 (1.267–3.175)
  1. “–,” data is non-significant. Abbreviation: CI confidence interval, HR hazard ratio. P < 0.05 was defined as the criterion for variable deletion when performing backward stepwise selection