Table 2 Univariate and multivariate Cox regression of clinicopathological for overall survival

 Age (< 60 years)

0.010

1.759 (1.142–2.708)

0.009

3.413 (1.355–8.597)

0.244

1.343 (0.818–2.205)

0.116

1.533 (0.900–2.611)

0.024

0.424 (0.201–0.894)

 Gender (male/female)

0.008

1.602 (1.129–2.271)

0.046

1.897 (1.010–3.564)

0.018

1.670 (1.093–2.553)

0.020

1.714 (1.089–2.697)

0.103

1.584 (0.912–2.752)

 Tumor size (5 cm)

0.913

1.018 (0.728–1.400)

0.735

0.909 (0.523–1.580)

0.480

1.157 (0.772–1.735)

0.233

1.297 (0.846–1.987)

0.435

0.816 (0.491–1.358)

  Rectum

Refer

Refer

Refer

Refer

Refer

  Left colon

0.908

1.025 (0.676–1.553)

0.670

1.168 (0.572–2.385)

0.926

0.975 (0.572–1.663)

0.926

0.975 (0.572–1.663)

0.942

1.025 (0.527–1.995)

  Right colon

0.464

0.859 (0.572–1.290)

0.860

0.939 (0.467–1.888)

0.249

0.728 (0.425–1.249)

0.249

0.728 (0.425–1.249)

0.967

1.013 (0.531–1.865)

 Pathological T stage

< 0.001

2.591 (1.562–4.297)

0.633

1.158 (0.634–2.116)

0.007

6.803 (1.675–27.633)

0.010

6.323 (1.554–25.722)

0.275

1.385 (0.541–1.486)

 Lymph node metastasis

< 0.001

2.802 (2.012–3.902)

0.041

4.410 (1.063–18.289)

0.558

0.828 (0.441–1.556)

–

–

–

–

 TNM stage

< 0.001

3.197 (2.271–4.501)

–

–

–

–

0.827

0.855 (0.210–3.481)

< 0.001

4.275 (2.203–8.298)

 Differentiation

< 0.001

1.889 (1.334–2.674)

0.833

1.084 (0.510–2.307)

0.019

1.083 (1.083–2.466)

0.126

1.407 (0.909–2.177)

0.074

1.742 (0.957–3.169)

 Lymphovascular invasion

< 0.001

3.251 (1.987–5.318)

0.163

1.538 (0.840–2.815)

0.011

1.702 (1.132–2.559)

0.019

1.670 (1.088–2.561)

0.036

1.782(1.039-3.056)

 Nervous invasion

0.140

1.497 (0.876–2.559)

0.281

1.759 (0.630–4.909)

0. 866

1.056 (0.562–1.985)

0.943

0.976 (0.503–1.893)

0.176

1.888 (0.752–4.741)

 Lymph nodes positive for CRC

< 0.001

4.006 (2.686–5.973)

0.007

16.949 (2.188–131.284)

< 0.001

2.178 (1.410–3.366)

< 0.001

0.723 (1.479–3.693)

0.001

5.338 (1.907–14.943)

 Colonic perforation

0.541

0.700 (0.223–2.198)

0.824

1.174 (0.285–4.829)

0.768

0.809 (0.198–3.303)

0.461

0.475 (0.066–3.428)

0.512

1.475 (0.462–4.711)

 Tumor budding

< 0.001

2.028 (1.400–2.938)

0.043

1.812 (1.019–3.221)

0.163

1.423 (0.867–2.336)

0.234

0.723 (0.424–1.232)

0.023

1.849 (1.087–3.146)

 Schistosomiasis

0.044

1.399 (1.009–1.940)

0.474

1.225 (0.703–2.132)

0.011

1.699 (1.128–2.560)

0.019

1.674 (1.087–2.577)

0.428

1.229 (0.738–2.049)

 Ulceration

0.624

0.9205 (0.660–1.282)

0.362

0.766 (0.4313–1.360)

0.971

1.008 (0.670–1.514)

0.649

1.104 (0.721–1.690)

0.189

0.698 (0.408–1.194)

 Histological type

0.921

1.025 (0.626–1.680)

0.797

0.886 (0.352–2.230)

0.870

0.952 (0.529–1.713)

0.708

0.889 (0.482–1.641)

0.902

0.948 (0.408–2.206)

 Gender

0.003

1.676 (1.178–2.384)

–

–

0.030

1.601 (1.047–2.450)

0.026

1.675 (1.064–2.639)

–

–

 Pathological T stage

–

–

–

–

0.012

6.042 (1.476–24.729)

0.025

5.040 (1.228–20.678)

–

–

 TNM stage

< 0.001

0.389 (0.267–0.567)

–

–

–

–

–

–

< 0.001

4.507 (2.303–8.818)

 Lymph node metastasis

–

–

 Tumor budding

–

–

0.014

0.513 (0.301–0.876)

 Differentiation

–

–

–

–

0.016

1.677 (1.101–2.555)

 Schistosomiasis

0.025

1.458 (1.049–2.027)

–

–

0.008

1.743 (1.153–2.635)

0.023

1.648 (1.070–2.538)

–

–

 Lymphovascular invasion

0.030

1.461 (1.036–2.060)

–

–

–

–

–

–

–

–

 Lymph nodes positive for CRC

< 0.001

2.256 (1.461–3.483)

0.007

16.8587 (2.176–130.580)

0.004

1.911 (1.230–2.969)

0.003

2.005 (1.267–3.175)

–

–