Skip to main content

Table 1 Clinical characteristics of the patient cohort

From: Natural disease progression and novel survival prediction model for hepatocellular carcinoma with spinal metastases: a 10-year single-center study

Clinical Characteristics

Total, n (%)

Missing, n (%)

Hazard ratio* (95% CI)

3-month survival (%)

6-month survival (%)

12-month survival (%)

P value**

Gender

 Male

60 (87.0)

0 (0)

Reference

45.0

33.3

16.7

0.520

 Female

9 (13.0)

 

0.79 (0.39, 1.61)

66.7

44.4

22.2

 

Age group (years)

       

 ≤ 60 years

50 (72.5)

0 (0)

Reference

52.0

38.0

22.0

0.036

 > 60 years

19 (27.5)

 

1.78 (1.03, 3.08)

36.8

26.3

5.3

 

Karnofskys Performance Status

 Good

17 (24.7)

0 (0)

Reference

82.4

70.6

41.2

0.003

 Moderate

25 (36.2)

 

2.29 (1.15, 4.54)

48.0

28.0

12.0

 

 Poor

27 (39.1)

 

3.16 (1.63, 6.15)

25.9

18.5

7.4

 

Cirrhosis

 No

21 (30.4)

7 (10.2)

Reference

66.7

47.6

23.8

0.024

 Yes

41 (59.4)

 

1.95 (1.08, 3.51)

39.0

29.3

17.1

 

Ascites

       

 No

33 (47.8)

10 (14.5)

Reference

66.7

51.5

27.3

0.001

 Yes

26 (37.7)

 

2.44 (1.39, 4.28)

26.9

15.4

7.7

 

Total bilirubin (mg/dL)

 < 2.0

55 (79.7)

1 (1.5)

Reference

56.4

43.6

21.8

< 0.001

 2.0–3.0

5 (7.2)

 

2.75 (1.06, 7.15)

20.0

0

0

 

 > 3.0

8 (11.6)

 

11.25 (4.39, 28.86)

0

0

0

 

Serum albumin (mg/dL)

 > 3.5

25 (36.2)

1 (1.5)

Reference

68.0

56.0

24.0

0.056

 2.8–3.5

26 (37.7)

 

1.38 (0.78, 2.45)

30.8

23.1

19.2

 

 < 2.8

17 (24.6)

 

2.17 (1.14, 4.14)

41.2

23.5

5.9

 

Number of primary tumor

 Single tumor

14 (20.3)

2 (2.9)

Reference

71.4

50.0

35.7

0.018

 Multiple tumors

53 (76.8)

 

2.20 (1.13, 4.29)

43.4

32.1

13.2

 

Portal vein involvement

       

 No

28 (40.6)

11 (15.9)

Reference

71.4

50.0

25.0

0.196

 Yes

30 (43.5)

 

1.43 (0.83, 2.45)

33.3

26.7

16.7

 

Visceral organ metastasis

 No

35 (50.7)

2 (2.9)

Reference

65.7

51.4

25.7

0.017

 Yes

32 (46.4)

 

1.35 (1.05, 1.73)

31.3

18.8

9.4

 

Number of vertebral columns involved

 1

30 (43.5)

3 (4.4)

Reference

53.3

40.0

20.0

0.751

 2

19 (27.5)

 

0.95 (0.52, 1.73)

57.9

36.8

15.8

 

 ≥ 3

17 (24.6)

 

1.21 (0.66, 2.22)

35.3

29.4

17.7

 

Number of extra spinal bone metastases

 0

32 (46.4)

7 (10.2)

Reference

59.4

43.8

25.0

0.256

 1–2

21 (30.4)

 

1.52 (0.86, 2.69)

42.9

33.3

14.3

 

 ≥ 3

9 (13.0)

 

1.64 (0.74, 3.63)

33.3

22.2

11.1

 
  1. Abbreviations: CI confidence interval
  2. *Hazard ratio from univariable Cox’s proportional hazard regression
  3. **P value from log-rank test