| Overall survival | Relapse-free survival | ||
---|---|---|---|---|
Characteristics | Univariate (p) | Multivariate (p) (hazard ratio) (95% CI) | Univariate (p) | Multivariate (p) (hazard ratio) (95% CI) |
Epidemiology | Â | Â | Â | Â |
 Sex, male | 0.62 |  | 0.66 |  |
 HBs-Ag positive | 0.07 |  | 0.32 |  |
 HCV-Ab positive | 0.52 |  | 0.87 |  |
 NBNC | 0.12 |  | 0.63 |  |
Biochemical factors | Â | Â | Â | Â |
 Platelets < 100,000/mm3 | 0.93 |  | 0.35 |  |
 PA < 80% | 0.17 |  | 0.04 | 0.40 (1.163) (0.813–1.665) |
 ChE < 180 IU/l | < 0.01 | < 0.01 (2.530) (1.684–3.800) | < 0.01 | < 0.01 (1.578) (1.125–2.214) |
 Albumin < 3.5 g/dl | < 0.01 | 0.58 (1.163) (0.679–1.992) | < 0.01 | 0.29 (1.282) (0.802–2.050) |
 ICGR15 ≥ 15% | 0.56 |  | 0.18 |  |
 AFP ≥ 20 ng/ml | < 0.01 | 0.03 (1.553) (1.041–2.315) | < 0.01 | 0.55 (1.095) (0.811–1.480) |
 PIVKA-II ≥ 400 mAU/ml | < 0.01 | 0.63 (0.905) (0.596–1.373) | < 0.01 | 0.94 (0.989) (0.732–1.337) |
Tumor factors | Â | Â | Â | Â |
 Tumor size ≥ 10 cm | < 0.01 | 0.01 (1.922) (1.128–3.274) | < 0.01 | 0.01 (1.654) (1.102–2.484) |
 Tumor number multiple | < 0.01 | 0.02 (1.559) (1.049–2.316) | < 0.01 | < 0.01 (2.223) (1.679–2.943) |
 Macroscopic type except simple nodular | 0.11 |  | < 0.01 | 0.13 (1.249) (0.931–1.675) |
Histological factors | Â | Â | Â | Â |
 Differentiation, poor | < 0.01 | 0.40 (1.179) (0.797–1.744) | 0.01 | 0.78 (0.959) (0.707–1.300) |
 PVI | < 0.01 | < 0.01 (2.653) (1.674–4.206) | < 0.01 | 0.03 (1.460) (1.027–2.078) |
 HVI | < 0.01 | 0.02 (1.889) (1.066–3.346) | < 0.01 | < 0.01 (1.980) (1.284–3.053) |
 Fibrosis | 0.42 |  | 0.60 |  |
Surgical factors | Â | Â | Â | Â |
 FRLR ≥ 50% | 0.63 |  | 0.83 |  |
 Non-anatomical resection | 0.20 |  | 0.06 |  |
 Blood loss ≥ 400 ml | 0.02 | 0.97 (1.005) (0.674–1.500) | 0.04 | 0.91 (1.014) (0.772–1.333) |