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Table 5 Prognostic factors for survival and recurrence of elderly patients

From: Prognoses, outcomes, and clinicopathological characteristics of very elderly patients with hepatocellular carcinoma who underwent hepatectomy

 

Overall survival

Relapse-free survival

Characteristics

Univariate (p)

Multivariate (p) (hazard ratio) (95% CI)

Univariate (p)

Multivariate (p) (hazard ratio) (95% CI)

Epidemiology

    

 Sex, male

0.62

 

0.66

 

 HBs-Ag positive

0.07

 

0.32

 

 HCV-Ab positive

0.52

 

0.87

 

 NBNC

0.12

 

0.63

 

Biochemical factors

    

 Platelets < 100,000/mm3

0.93

 

0.35

 

 PA < 80%

0.17

 

0.04

0.40 (1.163) (0.813–1.665)

 ChE < 180 IU/l

< 0.01

< 0.01 (2.530) (1.684–3.800)

< 0.01

< 0.01 (1.578) (1.125–2.214)

 Albumin < 3.5 g/dl

< 0.01

0.58 (1.163) (0.679–1.992)

< 0.01

0.29 (1.282) (0.802–2.050)

 ICGR15 ≥ 15%

0.56

 

0.18

 

 AFP ≥ 20 ng/ml

< 0.01

0.03 (1.553) (1.041–2.315)

< 0.01

0.55 (1.095) (0.811–1.480)

 PIVKA-II ≥ 400 mAU/ml

< 0.01

0.63 (0.905) (0.596–1.373)

< 0.01

0.94 (0.989) (0.732–1.337)

Tumor factors

    

 Tumor size ≥ 10 cm

< 0.01

0.01 (1.922) (1.128–3.274)

< 0.01

0.01 (1.654) (1.102–2.484)

 Tumor number multiple

< 0.01

0.02 (1.559) (1.049–2.316)

< 0.01

< 0.01 (2.223) (1.679–2.943)

 Macroscopic type except simple nodular

0.11

 

< 0.01

0.13 (1.249) (0.931–1.675)

Histological factors

    

 Differentiation, poor

< 0.01

0.40 (1.179) (0.797–1.744)

0.01

0.78 (0.959) (0.707–1.300)

 PVI

< 0.01

< 0.01 (2.653) (1.674–4.206)

< 0.01

0.03 (1.460) (1.027–2.078)

 HVI

< 0.01

0.02 (1.889) (1.066–3.346)

< 0.01

< 0.01 (1.980) (1.284–3.053)

 Fibrosis

0.42

 

0.60

 

Surgical factors

    

 FRLR ≥ 50%

0.63

 

0.83

 

 Non-anatomical resection

0.20

 

0.06

 

 Blood loss ≥ 400 ml

0.02

0.97 (1.005) (0.674–1.500)

0.04

0.91 (1.014) (0.772–1.333)

  1. PA prothrombin activity, ChE cholinesterase, ICGR15 indocyanine green retention rate at 15 min, AFP alpha-fetoprotein, PIVKA-II protein induced by vitamin K absence-II, PVI portal venous invasion, HVI hepatic venous invasion, FRLR future remnant liver rates