Skip to main content

Table 4 Prognostic factors for survival and recurrence of very elderly patients

From: Prognoses, outcomes, and clinicopathological characteristics of very elderly patients with hepatocellular carcinoma who underwent hepatectomy

 Overall survivalRelapse-free survival
CharacteristicsUnivariate (p)Multivariate (p) (hazard ratio) (95% CI)Univariate (p)Multivariate (p) (hazard ratio) (95% CI)
Epidemiology    
 Sex, male0.64 0.29 
 HBs-Ag positive0.24 0.09 
 HCV-Ab positive0.28 0.94 
 NBNC0.07 0.63 
Biochemical factors    
 Platelets < 100,000/mm30.50 0.42 
 PA < 80%< 0.010.02 (8.109) (1.227–53.587)0.57 
 ChE < 180 IU/l0.010.35 (2.021) (0.447–9.127)0.70 
 Albumin < 3.5 g/dl0.24 0.43 
 ICGR15 ≥ 15%0.06 0.77 
 AFP ≥ 20 ng/ml0.11 < 0.010.85 (0.911) (0.339–2.444)
 PIVKA-II ≥ 400 mAU/ml< 0.010.03 (9.838) (1.220–79.309)0.010.02 (4.038) (1.147–14.211)
Tumor factors    
 Tumor size ≥ 10 cm0.030.65 (0.707) (0.157–3.189)< 0.010.27 (0.424) (0.089–2.006)
 Tumor number multiple0.93 0.040.20 (2.115) (0.672–6.657)
 Macroscopic type except simple nodular0.42 0.030.05 (2.646) (0.982–7.127)
Histological factors    
 Differentiation, poor0.35 0.020.45 (1.440) (0.552–3.757)
 PVI0.75 0.010.01 (4.580) (1.342–15.629)
 HVI0.24 0.02< 0.01 (7.393) (1.923–28.424)
 Fibrosis0.57 0.020.01 (3.483) (1.258–9.644)
Surgical factors    
 FRLR < 50%0.030.81 (1.204) (0.245–5.911)0.17 
 Non-anatomical resection0.80 0.99 
 Blood loss ≥ 400 ml< 0.010.18 (5.000) (0.470–53.111)0.77 
  1. PA prothrombin activity, ChE cholinesterase, ICGR15 indocyanine green retention rate at 15 min, AFP alpha-fetoprotein, PIVKA-II protein induced by vitamin K absence-II, PVI portal venous invasion, HVI hepatic venous invasion, FRLR future remnant liver rates