Low expression of organic anion-transporting polypeptide 1B3 predicts a poor prognosis in hepatocellular carcinoma

Table 1 Association between OATP1B3 expression and clinicopathological features of HCC patients

Characteristics		n	OATP1B3 Low	OATP1B3 *High*	χ²	P
HCC		131	78	53	24.236	< 0.0001
Nontumor liver		89	23	66
Age (year)	≥ 50	56	33	23	0.015	0.902
Age (year)	< 50	75	45	30
Sex	Male	104	61	43	0.165	0.684
Sex	Female	27	17	10
Tumor size (cm)	≥ 5	88	59	29	6.266	0.012
Tumor size (cm)	< 5	43	19	24
TNM stage	I, II	50	19	31	15.578	< 0.0001
TNM stage	III, IV	81	59	22
Tumor differentiation	Well	9	0	9	17.716	< 0.0001
	Moderate	101	61	40
	Poor	21	17	4
Serum AFP	≥ 20 ng/mL	89	55	34	0.586	0.444
Serum AFP	< 20 ng/mL	42	23	19
Recurrence	Yes	81	56	25	8.109	0.004
Recurrence	No	50	22	28
HBsAg	Positive	106	61	45	0.918	0.338
HBsAg	Negative	25	17	8
Tumor number	Single	87	47	40	3.275	0.07
Tumor number	Multiple	44	31	13
Liver cirrhosis	Yes	91	53	38	0.209	0.647
Liver cirrhosis	No	40	25	15
Invasion	Yes	58	36	22	0.276	0.599
Invasion	No	73	42	31
Tumor capsule	Yes	45	27	18	0.006	0.938
Tumor capsule	No	86	51	35

AFP alpha fetoprotein, OATP1B3 organic anion transporting polypeptide 1B3, TNM stage tumor node metastasis stage, HCC hepatocellular carcinoma

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