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Table 3 CCRT versus primary radical surgery in subgroup analysis by age and T and N classification following multivariate analysis of stage IVA HPSCC patients

From: Treatment patterns and survival outcomes of advanced hypopharyngeal squamous cell carcinoma

VariableOSDFS
HR (95% CI)*p valueHR (95% CI)*p value
Treatment
 CCRTReference Reference 
 Surgery0.69 (0.51–0.93)0.0140.78 (0.59–1.03)0.079
Subgroup
 Age < 65 years
  Treatment
   CCRTReference Reference 
   Surgery0.76 (0.55–1.04)0.0870.82 (0.61–1.10)0.188
 Age ≥ 65 years
  Treatment
   CCRTReference Reference 
   Surgery0.33 (0.12–0.88)0.0270.53 (0.22–1.26)0.149
 T1–T3
  Treatment
   CCRTReference Reference 
   Surgery0.67 (0.39–1.15)0.1430.76 (0.46–1.24)0.267
 T4
  Treatment
   CCRTReference Reference 
   Surgery0.70 (0.48–1.00)0.0530.79 (0.56–1.12)0.186
 N0–N1
 Treatment
   CCRTReference Reference 
   Surgery0.92 (0.46–1.86)0.8161.11 (0.51–2.15)0.762
 N2
  Treatment    
   CCRTReference Reference 
   Surgery0.64 (0.46–0.90)0.0100.71 (0.52–0.97)0.033
  1. OS overall survival, DFS disease-free survival, WD well differentiated, MD moderately differentiated, PD poorly differentiated, UD undifferentiated, CCRT concurrent chemoradiotherapy
  2. *Model adjusted for sex, age, and histology grade