Table 3 CCRT versus primary radical surgery in subgroup analysis by age and T and N classification following multivariate analysis of stage IVA HPSCC patients
From: Treatment patterns and survival outcomes of advanced hypopharyngeal squamous cell carcinoma
Variable | OS | DFS | ||
|---|---|---|---|---|
HR (95% CI)* | p value | HR (95% CI)* | p value | |
Treatment | ||||
CCRT | Reference | Reference | ||
Surgery | 0.69 (0.51–0.93) | 0.014 | 0.78 (0.59–1.03) | 0.079 |
Subgroup | ||||
Age < 65 years | ||||
Treatment | ||||
CCRT | Reference | Reference | ||
Surgery | 0.76 (0.55–1.04) | 0.087 | 0.82 (0.61–1.10) | 0.188 |
Age ≥ 65 years | ||||
Treatment | ||||
CCRT | Reference | Reference | ||
Surgery | 0.33 (0.12–0.88) | 0.027 | 0.53 (0.22–1.26) | 0.149 |
T1–T3 | ||||
Treatment | ||||
CCRT | Reference | Reference | ||
Surgery | 0.67 (0.39–1.15) | 0.143 | 0.76 (0.46–1.24) | 0.267 |
T4 | ||||
Treatment | ||||
CCRT | Reference | Reference | ||
Surgery | 0.70 (0.48–1.00) | 0.053 | 0.79 (0.56–1.12) | 0.186 |
N0–N1 | ||||
Treatment | ||||
CCRT | Reference | Reference | ||
Surgery | 0.92 (0.46–1.86) | 0.816 | 1.11 (0.51–2.15) | 0.762 |
N2 | ||||
Treatment | ||||
CCRT | Reference | Reference | ||
Surgery | 0.64 (0.46–0.90) | 0.010 | 0.71 (0.52–0.97) | 0.033 |