Fig. 5

MiR-363 targeted NOB1 and mediated its expression. a The wild type (WT) and mutant (MUT) sequences on the 3′-UTR of NOB1 mRNA. b MiR-363 mimic inhibited the luciferase activity of cells that transfected with the wild-type 3′-UTR of NOB1 mRNA. c The mRNA level of NOB1 was reduced in miR-363 overexpressed MG63 cells, whereas increased in miR-363 knocking down cells. **P < 0.01; ^#P > 0.05; WT: wild type of ADAM9 3′UTR; MUT: mutant of ADAM9 3′UTR