Fig. 1

a Kaplan–Meier curve of OS. Median OS time was 2.62 years (red arrow), but survival was longer than 4 years in 24% of patients (green arrow). b Kaplan–Meier curve of 1st-line treatment PFS according to LTS. c Kaplan–Meier curve of OS according to LTS-associated treatments (bevacizumab-including 1st-line regimen, surgical resection of metastases, local non-surgical treatment of metastases). d Kaplan–Meier curve of OS according to local treatment of metastases (either by surgery or other approaches)