Fig. 2

Deficiency of circ-FOXM1 impeded melanoma cell proliferation, invasion, and glycolysis and promoted apoptosis. Si-NC or si-circ-FOXM1 was transfected into A2058 and A375 cells. a The expression of circ-FOXM1 in A2058 and A375 cells was measured by qRT-PCR assay. b, c The proliferation of A2058 and A375 cells was measured through MTT assay. d The apoptosis of A2058 and A375 cells was determined via flow cytometry analysis. e The invasion of A2058 and A375 cells was evaluated using transwell assay. f, g The levels of glucose consumption and lactate production were detected by specific kits. h, i The protein levels of HK2 and PKM2 were measured through western blot assay. *P < 0.05