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Table 1 Correlations between CBP/p300 expression and clinicopathological parameters

From: The prognostic capacities of CBP and p300 in locally advanced rectal cancer

Variable No. of patients CBP expression p300 expression p value
Low Medium High Low Medium High  
Total 93 28 (30.1%) 33 (35.5%) 32 (34.4%) 31 (33.3%) 30 (32.3%) 32 (34.4%) 0.86
 Female 30 7 (23.3%) 11 (36.7%) 12 (40.0%) 7 (23.3%) 10 (33.3%) 13 (43.3%) 0.96
 Male 63 21 (33.3%) 22 (34.9%) 20 (31.7%) 24 (38.1%) 20 (31.7%) 19 (30.2%) 0.85
Age (years)
  < 60 68 25 (36.8%) 21 (30.9%) 22 (32.4%) 25 (36.8%) 19 (27.9%) 24 (35.3%) 0.91
  ≥ 60 25 3 (12.0%) 12 (48.0%) 10 (40.0%) 6 (24.0%) 11 (44.0%) 8 (32.0%) 0.53
Tumour infiltration
 pT1 3 2 (66.7%) 0 (0%) 1 (33.3%) 0 (0%) 1 (33.3%) 2 (66.6%) 0.19
 pT2 18 6 (33.3%) 5 (27.8%) 7 (38.9%) 4 (22.2%) 6 (33.3%) 8 (44.4%) 0.76
 pT3 61 18 (29.5%) 23 (37.7%) 20 (32.8%) 23 (37.7%) 22 (36.1%) 16 (26.2%) 0.58
 pT4 11 2 (18.2%) 5 (45.5%) 4 (36.3%) 4 (36.4%) 1 (9.1%) 6 (54.5%) 0.15
Lymph node status
 pN0 53 15 (28.3%) 18 (34.0%) 20 (37.7%) 16 (30.2%) 18 (34.0%) 19 (35.8%) 0.97
 pN1 22 7 (31.8%) 9 (40.9%) 6 (27.3%) 8 (36.4%) 8 (36.4%) 6 (27.3%) 0.94
 pN2 18 6 (33.3%) 6 (33.3%) 6 (33.3%) 7 (38.9%) 4 (22.2%) 7 (38.9%) 0.76
Lymphatic vessel invasion
 L0 68 20 (29.4%) 24 (35.3%) 24 (35.3%) 20 (29.4%) 24 (35.3%) 24 (35.3%) 1
 L1 23 7 (30.4%) 9 (39.1%) 7 (30.4%) 10 (43.5%) 6 (26.1%) 7 (30.4%) 0.57
 LX 2 1 (50.0%) 0 (0%) 1 (50.0%) 1 (50.0%) 0 (0%) 1 (50.0%) n/a
Vein invasion
 V0 80 24 (30.0%) 27 (33.8%) 29 (36.2%) 26 (32.5%) 25 (31.2%) 29 (36.2%) 0.92
 V1 12 4 (33.3%) 6 (50.0%) 2 (16.7%) 5 (41,7%) 5 (41.7%) 2 (16.7%) 0.9
 VX 1 0 (0%) 0 (0%) 1 (100.0%) 0 (0%) 0 (0%) 1 (100%) n/a
Grade
 G1 0 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) n/a
 G2 67 20 (30.0%) 25 (37.2%) 22 (32.8%) 23 (34.3%) 21 (31.3%) 23 (34.3%) 0.75
 G3 25 8 (32.0%) 8 (32.0%) 9 (36.0%) 8 (32.0%) 9 (36.0%) 8 (32.0%) 0.94
 GX 1 0 (0%) 0 (0%) 1 (100%) 0 (0%) 0 (0%) 1 (100.0%) n/a
Resection boundaries
 R0 89 28 (31.5%) 31 (34.8%) 30 (33.7%) 30 (33.7%) 30 (33.7%) 29 (32.6%) 0.95
 R1 4 0 (0%) 2 (50.0%) 2 (50.0%) 1 (25.0%) 0 (0%) 3 (75.0%) 0.2
UICC
 pUICC I 14 6 (42.9%) 1 (7.1%) 7 (50.0%) 3 (21.4%) 5 (35.7%) 6 (42.9%) 0.15
 pUICC II 39 9 (23.0%) 17 (43.7%) 13 (33.3%) 13 (33.3%) 13 (33.3%) 13 (33.3%) 0.53
 pUICC III 38 13 (34.2%) 14 (36.9%) 11 (28.9%) 15 (39.5%) 12 (31.6%) 11 (28.9%) 0.86
 pUICC IV 2 0 (0%) 1 (50.0%) 1 (50.0%) 0 (0%) 0 (0%) 2 (100.0%) n/a
  1. The expression patterns of both enzymes were grouped according to the expression intensity as indicated below. pT histological tumour size, pN histological lymph node status, L invasion in lymphatic vessels, V invasion in venous vessels, G grade, R resection boundaries, and pUICC (Union Internationale Contre le Cancer) histological classification for malignant tumours. p values were determined using the chi-squared test