Extended versus non-extended lymphadenectomy during radical cystectomy for patients with bladder cancer: a meta-analysis of the effect on long-term and short-term outcomes

Table 1 Basic characteristics of included studies and long-term survival in both extended and non-extended LND groups

Author	Year	Study design	Type of LND		Number of cases		Median number of removed LNs		Follow-up, month (C/I)	Neoadjuvant or adjuvant therapy	NOS grade	Evidence level
Author	Year	Study design	C	I	C	I	C	I	Follow-up, month (C/I)	Neoadjuvant or adjuvant therapy	NOS grade	Evidence level
Poulsen	1998	Cohort studies	sLND	eLND	68	126	14	25	61.7/23.5	None	9	2b
Dhar	2008	Cohort studies	lLND	eLND	336	322	12	22	51/36	NR	8	2b
Abol-Enein	2011	Cohort studies	sLND	seLND	200	200	16	49	50.2	None	9	2b
Holmer	2009	Cohort studies	lLND	eLND	69	101	8	37	94/38	Adjuvant CT	9	2b
Hugen	2010	Cohort studies	sLND	seLND	206	54	9	46	NR	NR	7	2b
Jensen^a	2012	Cohort studies	lLND	mixed	204	265	6	23	113/45	None	9	2b
Simone	2012	Cohort studies	sLND	eLND	584	349	18	29	96	Adjuvant CT/RT	9	2b
Gschwend	2018	RCT	sLND	seLND	203	198	19	31	43	Adjuvant CT	9	1b
Adbi	2016	Cohort studies	sLND	eLND	105	105	9	21	18/19	Neoadjuvant CT	8	2b
Andrea	2019	Cohort studies	sLND	Mixed	200	34	13	NR	NR	NR	9	2b

C control group, I intervention group, LN lymph node, CT chemotherapy, RT radiotherapy, NR not recorded, lLND = limited LND, sLND standard LND, eLND extended LND, seLND super-extended LND, mixed a mixture of extended and super-extended LND, RCT randomized controlled trial, NOS Newcastle-Ottawa scale
^aThe number of removed LNs was the mean number in each group

ISSN: 1477-7819