Table 4 Multivariate analysis of prognostic factors in patients with hepatocellular carcinoma (HCC) conducted in a step-wise manner

  Distant metastases

Negative (n = 47)

0.605

0.602

0.091–4.011

Positive (n = 11)

  Overall tumor recurrence

Negative (n = 35)

1.828

0.272

0.623–5.368

Positive (n = 23)

  Angioinvasion

Negative (n = 28)

0.286

0.040

0.086–0.945

Positive (n = 30)

  Lymphangiosis carcinomatosa

Negative (n = 41)

1.700

0.330

0.585–4.940

Positive (n = 17)

  T status

T1&T2 (n = 29)

18.606

0.001

3.397–101.904

T3&T4

(n = 29)

  Angiopoietin-1 in TCA

Negative (n = 55)

4.859

0.021

1.274–18.537

Positive (n = 3)

  TEMs in TCA

Negative (n = 44)

2.837

0.051

0.997–8.071

Positive (n = 14)

  R status

Negative (n = 49)

4.346

0.061

0.936–20.174

Positive (n = 9)

  T status

T1&T2 (n = 29)

11.213

0.0001

2.997–41.957

T3&T4

(n = 29)

  Angioinvasion

Negative (n = 28)

0.458

0.122

0.170–1.234

Positive (n = 30)

  Lymph node involvement

Negative (n = 56)

0.311

0.255

0.042–2.322

Positive (n = 56)

  TEMs in TCA

Negative (n = 44)

0.391

0.083

0.135–1.132

Positive (n = 14)

  TEMs in TIF

Negative (n = 19)

3.677

0.049

1.1007–13.430

Positive (n = 39)

  Angiopoietin-1 in TIF

Negative (n = 9)

0.102

0.001

0.028–0.380

Positive (n = 49)

  Angiopoietin-1 in TCA

Negative (n = 55)

20.920

0.004

2.620–167.067

Positive (n = 3)