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Table 1 Characteristics of the included studies

From: Role of the intestinal microbiome in colorectal cancer surgery outcomes

Authors, yearStudy designNo. of patients1Tumor stageMicrobiome type, tissue sampleDetection methodBacteria2Short-term surgical outcomesLong-term oncological outcomesMean (SD) or median (range) follow-upAdjustments on covariates
Flanagan et al., 2014Cohort32Dukes staging A-DMAM, tumorBacterial DNA, qPCRFusobacterium nucleatumNot reported• Overall survival5 yearsNot specified
Flemer et al., 2018Cohort47AJCC
I-IV
MAM, tumorBacterial DNA, V3-V4 16S rRNACAGNot reported• Overall survival1371 days
(67–1792 days)
Tumor stage, age, gender, treatment with chemotherapy and/or radiotherapy and cancer site
Kosumi et al., 2018Cohort1313AJCC
I-IV
MAM, tumorBacterial DNA, qPCRBifidobacteriumNot reported• Cancer-specific mortality
• Overall mortality
14.3 years
(10–18.3 years)
Microsatellite instability status, CpG island methylator phenotype, long-interspersed nucleotide element-1 methylation, KRAS, BRAF, and PIK3CA mutations.
Mima et al., 2016Cohort1069AJCC
I-IV
MAM, tumorBacterial DNA, qPCRFusobacterium nucleatumNot reported• Cancer-specific mortality
• Overall mortality
10.7 years
(7–15.8 years)
Age, sex, year of diagnosis, family history of colorectal carcinoma in a first-degree relative, tumor location, microsatellite instability (MSI, mismatch repair deficiency), CpG island methylator phenotype (CIMP), KRAS, BRAF, and PIK3CA mutations, and LINE-1 hypomethylation (low-level methylation).
Van Praagh et al., 2017Case-control118Not specified3MAM, anastomosisBacterial DNA, V3-V4 16S rRNAAllAnastomotic leakageNot reportedNot reportedNot specified
Wei et al., 2016Cohort180AJCC
I-IV
MAM, tumorBacterial DNA, V4 16S rRNAAllNot reported• Overall survival
• Disease-free survival
47 months
(36–59 months)
Not specified
Yan et al., 2017Cohort208AJCC
III-IV
MAM, tumorBacterial DNA, qPCRFusobacterium nucleatumNot reported• Cancer-specific survival
• Disease-free survival
Not reportedNot specified
Yu et al., 2017Cohort296AJCC
II-III
MAM, tumorBacterial DNA, qPCRFusobacterium nucleatumNot reported• Recurrence-free survivalNot reportedNot specified
  1. AJCC, American Joint Committee on Cancer; MAM, mucosa-associated microbiome; CAG, tissue-associated microbial co-abundance groups; qPCR, quantitative polymerase chain reaction
  2. 1Patients included in the analysis of the microbiome and its association with short- or long-term outcomes
  3. 2Bacteria analyzed for an association with short- or long-term outcomes
  4. 3The study also included 6 non-oncological patients