Table 1 Characteristics of the clinical trials included in the meta-analysis
Study | Country | Study years | Sex (F/M) | Lymphatic invasion (yes/no) | Perineural invasion (yes/no) | Differentiation (well/moderate poor) | Median follow-up (months) | Location | Ductal resection margin status | Patients | Quality |
|---|---|---|---|---|---|---|---|---|---|---|---|
Sasakai, 2007 [30] | Japan | 1985–2005 | NR | 115/13 | 102/26 | 50/78 | NR | Perihilar (n = 51) Distal (n = 77) | R0 | 105 | 7 |
R1-CIS | 12 | ||||||||||
R1-INV | 11 | ||||||||||
Endo, 2008 [31] | USA | 1992–2005 | NR | NR | NR | NR | 26 ± 2.5(1–103) | Perihilar (n = 82) | R0 | 66 | 7 |
R1-CIS | 16 | ||||||||||
Igami 2009 [32] | Japan | 1977–2005 | 162/309 | NR | NR | NR | NR | Perihilar (n = 351) Distal (n = 120) | R0 | 410 | 6 |
R1-CIS | 14 | ||||||||||
R1-INV | 47 | ||||||||||
Nakanishi, 2010 [33] | Japan | 1989–2007 | 25/100 | NR | 106/19 | 38/87 | NR | Perihilar (n = 103) Distal (n = 22) | R0 | 96 | 8 |
R1-CIS | 10 | ||||||||||
R1-INV | 19 | ||||||||||
Wakai, 2011 [34] | Japan | 1988–2007 | 41/69 | NR | NR | 27/83 | 99 (1–259) | Perihilar (n = 57) Distal (n = 53) | R0 | 85 | 8 |
R1-CIS | 14 | ||||||||||
R1-INV | 11 | ||||||||||
Han, 2013 [35] | South Korea | 1995–2007 | 129/335 | NR | NR | NR | 32 (1–181) | Perihilar (n = 208) Distal (n = 246) Diffuse (n = 10) | R0 | 340 | 8 |
R1-CIS | 39 | ||||||||||
R1-INV | 85 | ||||||||||
Oguro, 2015 [36] | Japan | 2000–2011 | 49/100 | NR | NR | 42/107 | 26.5 (2.20–143.7) | Perihilar (n = 149) | R0 | 128 | 7 |
R1-CIS | 21 | ||||||||||
Kurahara, 2016 [18] | Japan | 2002–2014 | 27/73 | NR | NR | 49/51 | 25.3 | Perihilar (n = 35) Distal (n = 65) | R0 | 69 | 8 |
R1-CIS | 16 | ||||||||||
R1-INV | 15 | ||||||||||
Tsukahara, 2017 [19] | Japan | 1998–2013 | 59/113 | 66/106 | 103/69 | 93/79 | 86.9 | Perihilar (n = 144) Distal (n = 28) | R0 | 148 | 8 |
R1-CIS | 18 | ||||||||||
R1-INV | 6 | ||||||||||
Higuchi, 2017 [17] | Japan | 2004–2013 | 58/105 | NR | NR | NR | NR | Perihilar (n = 163) | R0 | 113 | 7 |
R1-HGD/CIS | 22 | ||||||||||
R1-INV | 28 | ||||||||||
Park, 2019 [12] | South Korea | 2008–2016 | 83/110 | NR | 137/56 | 42/151 | 35.9 (22.4–58.4) | Distal (n = 193) | R0 | 174 | 7 |
R1-CIS/HGD | 12 | ||||||||||
R1-INV | 7 |