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Table 1 Characteristics of the clinical trials included in the meta-analysis

From: Does high-grade dysplasia/carcinoma in situ of the biliary duct margin affect the prognosis of extrahepatic cholangiocarcinoma? A meta-analysis

StudyCountryStudy yearsSex (F/M)Lymphatic invasion (yes/no)Perineural invasion (yes/no)Differentiation (well/moderate poor)Median follow-up (months)LocationDuctal resection margin statusPatientsQuality
Sasakai, 2007 [30]Japan1985–2005NR115/13102/2650/78NRPerihilar (n = 51)
Distal (n = 77)
R01057
R1-CIS12
R1-INV11
Endo, 2008 [31]USA1992–2005NRNRNRNR26 ± 2.5(1–103)Perihilar (n = 82)R0667
R1-CIS16
Igami 2009 [32]Japan1977–2005162/309NRNRNRNRPerihilar (n = 351) Distal (n = 120)R04106
R1-CIS14
R1-INV47
Nakanishi, 2010 [33]Japan1989–200725/100NR106/1938/87NRPerihilar (n = 103) Distal (n = 22)R0968
R1-CIS10
R1-INV19
Wakai, 2011 [34]Japan1988–200741/69NRNR27/8399 (1–259)Perihilar (n = 57)
Distal (n = 53)
R0858
R1-CIS14
R1-INV11
Han, 2013 [35]South Korea1995–2007129/335NRNRNR32 (1–181)Perihilar (n = 208) Distal (n = 246) Diffuse (n = 10)R03408
R1-CIS39
R1-INV85
Oguro, 2015 [36]Japan2000–201149/100NRNR42/10726.5 (2.20–143.7)Perihilar (n = 149)R01287
R1-CIS21
Kurahara, 2016 [18]Japan2002–201427/73NRNR49/5125.3Perihilar (n = 35)
Distal (n = 65)
R0698
R1-CIS16
R1-INV15
Tsukahara, 2017 [19]Japan1998–201359/11366/106103/6993/7986.9Perihilar (n = 144) Distal (n = 28)R01488
R1-CIS18
R1-INV6
Higuchi, 2017 [17]Japan2004–201358/105NRNRNRNRPerihilar (n = 163)R01137
R1-HGD/CIS22
R1-INV28
Park, 2019 [12]South Korea2008–201683/110NR137/5642/15135.9 (22.4–58.4)Distal (n = 193)R01747
R1-CIS/HGD12
R1-INV7