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Table 1 Characteristics of the clinical trials included in the meta-analysis

From: Does high-grade dysplasia/carcinoma in situ of the biliary duct margin affect the prognosis of extrahepatic cholangiocarcinoma? A meta-analysis

Study Country Study years Sex (F/M) Lymphatic invasion (yes/no) Perineural invasion (yes/no) Differentiation (well/moderate poor) Median follow-up (months) Location Ductal resection margin status Patients Quality
Sasakai, 2007 [30] Japan 1985–2005 NR 115/13 102/26 50/78 NR Perihilar (n = 51)
Distal (n = 77)
R0 105 7
R1-CIS 12
R1-INV 11
Endo, 2008 [31] USA 1992–2005 NR NR NR NR 26 ± 2.5(1–103) Perihilar (n = 82) R0 66 7
R1-CIS 16
Igami 2009 [32] Japan 1977–2005 162/309 NR NR NR NR Perihilar (n = 351) Distal (n = 120) R0 410 6
R1-CIS 14
R1-INV 47
Nakanishi, 2010 [33] Japan 1989–2007 25/100 NR 106/19 38/87 NR Perihilar (n = 103) Distal (n = 22) R0 96 8
R1-CIS 10
R1-INV 19
Wakai, 2011 [34] Japan 1988–2007 41/69 NR NR 27/83 99 (1–259) Perihilar (n = 57)
Distal (n = 53)
R0 85 8
R1-CIS 14
R1-INV 11
Han, 2013 [35] South Korea 1995–2007 129/335 NR NR NR 32 (1–181) Perihilar (n = 208) Distal (n = 246) Diffuse (n = 10) R0 340 8
R1-CIS 39
R1-INV 85
Oguro, 2015 [36] Japan 2000–2011 49/100 NR NR 42/107 26.5 (2.20–143.7) Perihilar (n = 149) R0 128 7
R1-CIS 21
Kurahara, 2016 [18] Japan 2002–2014 27/73 NR NR 49/51 25.3 Perihilar (n = 35)
Distal (n = 65)
R0 69 8
R1-CIS 16
R1-INV 15
Tsukahara, 2017 [19] Japan 1998–2013 59/113 66/106 103/69 93/79 86.9 Perihilar (n = 144) Distal (n = 28) R0 148 8
R1-CIS 18
R1-INV 6
Higuchi, 2017 [17] Japan 2004–2013 58/105 NR NR NR NR Perihilar (n = 163) R0 113 7
R1-HGD/CIS 22
R1-INV 28
Park, 2019 [12] South Korea 2008–2016 83/110 NR 137/56 42/151 35.9 (22.4–58.4) Distal (n = 193) R0 174 7
R1-CIS/HGD 12
R1-INV 7