Mutational spectrum of tobacco associated oral squamous carcinoma and its therapeutic significance

Table 3 Disease free survival and overall survival of various clinicopathological factors and studied mutations

Variables	30 month disease free survival (%)	p value	30 month overall survival (%)	p value
Age (year)		0.001*		0.003*
< 46	36.4		45.5
> 46	75.0		87.5
Site of tumor		0.641		0.665
Tongue	61.5		69.2
Buccal mucosa	50.0		66.7
Lower alveolus	66.7		50.0
Upper alveolus	100		100
Lower lip	50.0		100
HPE size (cm)		0.846		0.720
< 4	54.3		74.3
≥ 4	63.6		45.5
Lymph node (HPE)		0.250		0.021*
Positive	42.9		42.9
Negative	62.5		78.1
Extra nodal extension (ENE)		0.464		0.997
Present	42.9		71.4
Absent	59.0		66.7
Depth of invasion (mm)		0.731		0.008*
< 5	50.0		100
≥ 5, > 10	58.3		79.2
< 10	55.6		44.4
Vascular invasion		0.018*		0.042*
Positive	23.1		38.5
Negative	69.7		78.8
PNI		0.196		0.134
Positive	40.0		50.0
Negative	69.2		80.8
Adjuvant RT		0.731		0.042*
Yes	52.6		47.4
No	59.3		81.5
Mutations
TP53		0.176		0.082
Present	47.4		52.6
Absent	63.0		77.8
CDKN2A		0.320		0.431
Present	72.7		81.8
Absent	51.4		62.9
PIK3CA		0.148		0.221
Present	100		100
Absent	53.5		65.1
HRAS		0.629		0.761
Present	62.5		75.0
Absent	55.3		65.8

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