Skip to main content

Advertisement

Table 3 Disease free survival and overall survival of various clinicopathological factors and studied mutations

From: Mutational spectrum of tobacco associated oral squamous carcinoma and its therapeutic significance

Variables30 month disease free survival (%)p value30 month overall survival (%)p value
Age (year) 0.001* 0.003*
< 4636.4 45.5 
 > 4675.0 87.5 
Site of tumor 0.641 0.665
 Tongue61.5 69.2 
 Buccal mucosa50.0 66.7 
 Lower alveolus66.7 50.0 
 Upper alveolus100 100 
 Lower lip50.0 100 
HPE size (cm) 0.846 0.720
 < 454.3 74.3 
 ≥ 463.6 45.5 
Lymph node (HPE) 0.250 0.021*
 Positive42.9 42.9 
 Negative62.5 78.1 
Extra nodal extension (ENE) 0.464 0.997
 Present42.9 71.4 
 Absent59.0 66.7 
Depth of invasion (mm) 0.731 0.008*
 < 550.0 100 
 ≥ 5, > 1058.3 79.2 
 < 1055.6 44.4 
Vascular invasion 0.018* 0.042*
 Positive23.1 38.5 
 Negative69.7 78.8 
PNI 0.196 0.134
 Positive40.0 50.0 
 Negative69.2 80.8 
Adjuvant RT 0.731 0.042*
 Yes52.6 47.4 
 No59.3 81.5 
Mutations    
 TP53 0.176 0.082
 Present47.4 52.6 
 Absent63.0 77.8 
CDKN2A 0.320 0.431
 Present72.7 81.8 
 Absent51.4 62.9 
PIK3CA 0.148 0.221
 Present100 100 
 Absent53.5 65.1 
HRAS 0.629 0.761
 Present62.5 75.0 
 Absent55.3 65.8 
  1. *statistically significant