From: Mutational spectrum of tobacco associated oral squamous carcinoma and its therapeutic significance
 | TP53 | p value | CDKN2A | p value | PIK3CA | p value | HRAS | p value | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Positive (n = 19) | Negative (n = 27) | Â | Positive (n = 11) | Negative (n = 35) | Â | Positive (n = 3) | Negative (n = 43) | Â | Positive (n = 8) | Negative (n = 38) | Â | |
HPE size (cm) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
≥ 4 (n = 10) | 8 | 3 | 0.032* | 3 | 8 | 0.526 | 2 | 9 | 0.073 | 1 | 10 | 0.405 |
< 4 (n = 26) | 11 | 24 | Â | 8 | 27 | Â | 1 | 34 | Â | 7 | 28 | Â |
Site | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Tongue |  |  | 0.462 |  |  | 0.330 |  |  | 0.261 |  |  | 0.882 |
 Yes | 6 | 7 |  | 2 | 11 |  | 0 | 13 |  | 2 | 11 |  |
 No | 13 | 20 |  | 9 | 24 |  | 3 | 30 |  | 6 | 27 |  |
Buccal mucosa | Â | Â | 0.402 | Â | Â | 0.301 | Â | Â | 0.499 | Â | Â | 0.892 |
 Yes | 9 | 15 |  | 7 | 17 |  | 1 | 23 |  | 4 | 20 |  |
 No | 10 | 12 |  | 11 | 18 |  | 2 | 20 |  | 4 | 18 |  |
Lower alveolus | Â | Â | 0.484 | Â | Â | 0.555 | Â | Â | 0.004* | Â | Â | 0.228 |
 Yes | 3 | 3 |  | 1 | 5 |  | 2 | 4 |  | 0 | 6 |  |
 No | 16 | 24 |  | 10 | 30 |  | 1 | 39 |  | 8 | 32 |  |
Upper alveolus | Â | Â | 0.413 | Â | Â | 0.239 | Â | Â | 1.000 | Â | Â | 1.000 |
 Yes | 1 | 0 |  | 1 | 0 |  | 0 | 1 |  | 0 | 1 |  |
 No | 18 | 27 |  | 10 | 35 |  | 3 | 42 |  | 8 | 37 |  |
Lower lip | Â | Â | 0.339 | Â | Â | 1.000 | Â | Â | 1.000 | Â | Â | 0.002* |
 Yes | 0 | 2 |  | 0 | 2 |  | 0 | 2 |  | 2 | 0 |  |
 No | 19 | 25 |  | 11 | 33 |  | 3 | 41 |  | 6 | 38 |  |
HPE grade | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Moderately differentiated | 10 | 10 | 0.337 | 3 | 17 | 0.371 | 2 | 18 | 0.686 | 3 | 17 | 0.705 |
 Well differentiated | 9 | 15 |  | 7 | 17 |  | 1 | 23 |  | 5 | 19 |  |
 Poorly differentiated | 0 | 2 |  | 1 | 1 |  | 0 | 2 |  | 0 | 2 |  |
Vascular invasion | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Yes | 7 | 6 | 0.225 | 2 | 11 | 0.330 | 1 | 12 | 1.000 | 2 | 11 | 0.882 |
 No | 12 | 21 |  | 9 | 24 |  | 2 | 31 |  | 6 | 27 |  |
Perineural invasion | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Yes | 9 | 11 | 0.442 | 3 | 17 | 0.187 | 3 | 17 | 0.041* | 2 | 18 | 0.246 |
 No | 10 | 16 |  | 8 | 18 |  | 0 | 26 |  | 6 | 20 |  |
Depth invasion | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 < 5 | 3 | 1 | 0.143 | 1 | 3 | 0.642 | 0 | 4 | 0.571 | 0 | 4 | 0.316 |
 5–10 | 7 | 17 |  | 7 | 17 |  | 1 | 23 |  | 6 | 18 |  |
 > 10 | 9 | 9 |  | 3 | 15 |  | 2 | 16 |  | 2 | 16 |  |
Lymph node positivity | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Yes | 6 | 8 | 0.570 | 3 | 11 | 0.556 | 1 | 13 | 0.910 | 3 | 11 | 0.633 |
 No | 13 | 19 |  | 8 | 24 |  | 2 | 30 |  | 5 | 27 |  |
Extra nodal extension | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Yes | 2 | 5 | 0.457 | 1 | 6 | 0.459 | 0 | 7 | 1.000 | 1 | 6 | 1.000 |
 No | 17 | 22 |  | 10 | 29 |  | 3 | 36 |  | 7 | 32 |  |
T status | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 T2 | 8 | 15 | 0.660 | 8 | 15 | 0.127 | 0 | 23 | 0.036* | 5 | 18 | 0.057 |
 T3 | 4 | 4 |  | 0 | 8 |  | 0 | 8 |  | 3 | 5 |  |
 T4 | 7 | 8 |  | 3 | 12 |  | 3 | 12 |  | 0 | 15 |  |
Stage | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 I | 1 | 0 | 0.453 | 0 | 1 | 0.282 | 0 | 1 | 0.086 | 0 | 1 | 0.880 |
 II | 9 | 13 |  | 8 | 14 |  | 0 | 22 |  | 4 | 18 |  |
 III | 3 | 4 |  | 0 | 7 |  | 0 | 7 |  | 1 | 6 |  |
 IVa | 6 | 7 |  | 2 | 11 |  | 3 | 10 |  | 3 | 10 |  |
 IVb | 0 | 3 |  | 1 | 2 |  | 0 | 3 |  | 0 | 3 |  |