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Table 2 Relationship of TP53, CDKN2A, PIK3CA, HRAS mutation with clinical-pathological factors

From: Mutational spectrum of tobacco associated oral squamous carcinoma and its therapeutic significance

 TP53p valueCDKN2Ap valuePIK3CAp valueHRASp value
Positive (n = 19)Negative (n = 27) Positive (n = 11)Negative (n = 35) Positive (n = 3)Negative (n = 43) Positive (n = 8)Negative (n = 38) 
HPE size (cm)            
≥ 4 (n = 10)830.032*380.526290.0731100.405
< 4 (n = 26)1124 827 134 728 
Site            
 Tongue  0.462  0.330  0.261  0.882
 Yes67 211 013 211 
 No1320 924 330 627 
Buccal mucosa  0.402  0.301  0.499  0.892
 Yes915 717 123 420 
 No1012 1118 220 418 
Lower alveolus  0.484  0.555  0.004*  0.228
 Yes33 15 24 06 
 No1624 1030 139 832 
Upper alveolus  0.413  0.239  1.000  1.000
 Yes10 10 01 01 
 No1827 1035 342 837 
Lower lip  0.339  1.000  1.000  0.002*
 Yes02 02 02 20 
 No1925 1133 341 638 
HPE grade            
 Moderately differentiated10100.3373170.3712180.6863170.705
 Well differentiated915 717 123 519 
 Poorly differentiated02 11 02 02 
Vascular invasion            
 Yes760.2252110.3301121.0002110.882
 No1221 924 231 627 
Perineural invasion            
 Yes9110.4423170.1873170.041*2180.246
 No1016 818 026 620 
Depth invasion            
 < 5310.143130.642040.571040.316
 5–10717 717 123 618 
 > 1099 315 216 216 
Lymph node positivity            
 Yes680.5703110.5561130.9103110.633
 No1319 824 230 527 
Extra nodal extension            
 Yes250.457160.459071.000161.000
 No1722 1029 336 732 
T status            
 T28150.6608150.1270230.036*5180.057
 T344 08 08 35 
 T478 312 312 015 
Stage            
 I100.453010.282010.086010.880
 II913 814 022 418 
 III34 07 07 16 
 IVa67 211 310 310 
 IVb03 12 03 03 
  1. *statistically significant