|
Factors
|
No. of studies
|
No. of patients
|
HR (95% CI)
|
P
|
Heterogeneity
|
|---|
|
I2 (%)
|
P
h
|
|---|
|
Overall
|
16
|
2275
|
1.43 (1.27–1.62)
|
< 0.00001
|
83
|
< 0.00001
|
|
Ethnicity
| | |
|
Caucasian
|
4
|
665
|
1.26 (0.92–1.72)
|
0.16
|
71
|
0.02
|
|
Asian
|
12
|
1610
|
1.64 (1.28–2.10)
|
< 0.0001
|
83
|
< 0.00001
|
|
Histology
| |
|
Glioblastoma
|
10
|
1431
|
1.29 (1.13–1.47)
|
0.0002
|
84
|
< 0.00001
|
|
Glioma(various grades)
|
6
|
844
|
1.68 (1.40–2.01)
|
< 0.00001
|
0
|
0.74
|
|
Cutoff value
| |
|
= 4
|
9
|
1168
|
1.55 (1.22–1.97)
|
0.0003
|
74
|
0.0002
|
|
≠ 4
|
7
|
1107
|
1.52 (1.06–2.19)
|
0.02
|
88
|
< 0.00001
|
|
NOS score
| |
|
≤ 5
|
11
|
1521
|
1.46 (1.17–1.83)
|
0.001
|
77
|
< 0.00001
|
|
> 5
|
5
|
754
|
1.72 (1.09–2.72)
|
0.02
|
90
|
< 0.00001
|
|
Analysis method
| |
|
Univariate
|
3
|
445
|
1.69 (1.06–2.67)
|
0.03
|
77
|
0.01
|
|
Multivariate
|
13
|
1830
|
1.31 (1.16–1.48)
|
< 0.0001
|
78
|
< 0.00001
|
|
Sampling time
| |
|
Preoperative
|
11
|
1461
|
1.29 (1.14–1.45)
|
< 0.0001
|
78
|
< 0.00001
|
|
Postoperative
|
2
|
441
|
1.36 (0.69–2.70)
|
0.38
|
74
|
0.05
|
- HR hazard ratio, CI confidence interval, P P value for statistical significance based on Z test, Ph P value for heterogeneity based on Q test
