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Table 2 Subgroup analysis of the association between NLR and OS

From: Prognostic impact of neutrophil-to-lymphocyte ratio in gliomas: a systematic review and meta-analysis

Factors No. of studies No. of patients HR (95% CI) P Heterogeneity
I2 (%) P h
Overall 16 2275 1.43 (1.27–1.62) < 0.00001 83 < 0.00001
Ethnicity   
 Caucasian 4 665 1.26 (0.92–1.72) 0.16 71 0.02
 Asian 12 1610 1.64 (1.28–2.10) < 0.0001 83 < 0.00001
Histology  
 Glioblastoma 10 1431 1.29 (1.13–1.47) 0.0002 84 < 0.00001
 Glioma(various grades) 6 844 1.68 (1.40–2.01) < 0.00001 0 0.74
Cutoff value  
 = 4 9 1168 1.55 (1.22–1.97) 0.0003 74 0.0002
 ≠ 4 7 1107 1.52 (1.06–2.19) 0.02 88 < 0.00001
NOS score  
 ≤ 5 11 1521 1.46 (1.17–1.83) 0.001 77 < 0.00001
 > 5 5 754 1.72 (1.09–2.72) 0.02 90 < 0.00001
Analysis method  
 Univariate 3 445 1.69 (1.06–2.67) 0.03 77 0.01
 Multivariate 13 1830 1.31 (1.16–1.48) < 0.0001 78 < 0.00001
Sampling time  
 Preoperative 11 1461 1.29 (1.14–1.45) < 0.0001 78 < 0.00001
 Postoperative 2 441 1.36 (0.69–2.70) 0.38 74 0.05
  1. HR hazard ratio, CI confidence interval, P P value for statistical significance based on Z test, Ph P value for heterogeneity based on Q test