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Table 2 Subgroup analysis of the association between NLR and OS

From: Prognostic impact of neutrophil-to-lymphocyte ratio in gliomas: a systematic review and meta-analysis

Factors

No. of studies

No. of patients

HR (95% CI)

P

Heterogeneity

I2 (%)

P h

Overall

16

2275

1.43 (1.27–1.62)

< 0.00001

83

< 0.00001

Ethnicity

  

 Caucasian

4

665

1.26 (0.92–1.72)

0.16

71

0.02

 Asian

12

1610

1.64 (1.28–2.10)

< 0.0001

83

< 0.00001

Histology

 

 Glioblastoma

10

1431

1.29 (1.13–1.47)

0.0002

84

< 0.00001

 Glioma(various grades)

6

844

1.68 (1.40–2.01)

< 0.00001

0

0.74

Cutoff value

 

 = 4

9

1168

1.55 (1.22–1.97)

0.0003

74

0.0002

 ≠ 4

7

1107

1.52 (1.06–2.19)

0.02

88

< 0.00001

NOS score

 

 ≤ 5

11

1521

1.46 (1.17–1.83)

0.001

77

< 0.00001

 > 5

5

754

1.72 (1.09–2.72)

0.02

90

< 0.00001

Analysis method

 

 Univariate

3

445

1.69 (1.06–2.67)

0.03

77

0.01

 Multivariate

13

1830

1.31 (1.16–1.48)

< 0.0001

78

< 0.00001

Sampling time

 

 Preoperative

11

1461

1.29 (1.14–1.45)

< 0.0001

78

< 0.00001

 Postoperative

2

441

1.36 (0.69–2.70)

0.38

74

0.05

  1. HR hazard ratio, CI confidence interval, P P value for statistical significance based on Z test, Ph P value for heterogeneity based on Q test