Factors | No. of studies | No. of patients | HR (95% CI) | P | Heterogeneity | |
---|---|---|---|---|---|---|
I2 (%) | P h | |||||
Overall | 16 | 2275 | 1.43 (1.27–1.62) | < 0.00001 | 83 | < 0.00001 |
Ethnicity | ||||||
Caucasian | 4 | 665 | 1.26 (0.92–1.72) | 0.16 | 71 | 0.02 |
Asian | 12 | 1610 | 1.64 (1.28–2.10) | < 0.0001 | 83 | < 0.00001 |
Histology | ||||||
Glioblastoma | 10 | 1431 | 1.29 (1.13–1.47) | 0.0002 | 84 | < 0.00001 |
Glioma(various grades) | 6 | 844 | 1.68 (1.40–2.01) | < 0.00001 | 0 | 0.74 |
Cutoff value | ||||||
= 4 | 9 | 1168 | 1.55 (1.22–1.97) | 0.0003 | 74 | 0.0002 |
≠ 4 | 7 | 1107 | 1.52 (1.06–2.19) | 0.02 | 88 | < 0.00001 |
NOS score | ||||||
≤ 5 | 11 | 1521 | 1.46 (1.17–1.83) | 0.001 | 77 | < 0.00001 |
> 5 | 5 | 754 | 1.72 (1.09–2.72) | 0.02 | 90 | < 0.00001 |
Analysis method | ||||||
Univariate | 3 | 445 | 1.69 (1.06–2.67) | 0.03 | 77 | 0.01 |
Multivariate | 13 | 1830 | 1.31 (1.16–1.48) | < 0.0001 | 78 | < 0.00001 |
Sampling time | ||||||
Preoperative | 11 | 1461 | 1.29 (1.14–1.45) | < 0.0001 | 78 | < 0.00001 |
Postoperative | 2 | 441 | 1.36 (0.69–2.70) | 0.38 | 74 | 0.05 |