Skip to main content

Table 2 Subgroup analyses for OS, PFS, and RFS

From: Prognostic role of pretreatment thrombocytosis on survival in patients with cervical cancer: a systematic review and meta-analysis

Outcomes Factors Groups HR and 95% CI P value Heterogeneity (%) P value for heterogeneity P value between subgroups
OS Publication year Before 2010 1.85 (1.43–2.40) < 0.001 22.3 0.266 0.039
2010 or after 1.29 (0.94–1.77) 0.111 67.6 0.001
Country Eastern 1.15 (0.77–1.72) 0.485 74.2 <0.001 0.013
Western 1.78 (1.47–2.15) <0.001 4.2 0.400
Sample size ≥ 100 1.56 (1.28–1.89) <0.001 44.6 0.036 0.029
< 100 1.64 (0.31–8.64) 0.562 85.0 0.001
Mean age (years) ≥ 50.0 1.16 (0.63–2.13) 0.638 83.7 <0.001 0.055
< 50.0 1.67 (1.34–2.08) <0.001 17.1 0.295
Not reported 1.68 (1.26–2.24) <0.001 0.0 0.425
Treatment strategy Surgery alone 1.64 (1.05–2.57) 0.031 66.0 0.012 0.774
Other 1.41 (1.06–1.89) 0.020 65.9 0.002
Cutoff value ≥ 300 1.53 (1.14–2.05) 0.004 67.7 <0.001 0.851
< 300 1.43 (0.97–2.11) 0.069 46.4 0.113
Adjusted Yes 1.68 (1.38–2.05) <0.001 0.0 0.748 0.149
No 1.39 (0.98–1.96) 0.063 70.7 <0.001
Study quality High 1.67 (1.37–2.03) <0.001 0.0 0.917 0.174
Low 1.44 (1.00–2.07) 0.052 71.6 <0.001
PFS Publication year Before 2010 1.54 (0.80–2.96) 0.196 0.699
2010 or after 1.29 (1.02–1.64) 0.036 32.4 0.170
Country Eastern 1.18 (0.90–1.55) 0.241 33.7 0.183 0.115
Western 1.71 (1.22–2.39) 0.002 0.0 0.790
Sample size ≥ 100 1.39 (1.16–1.67) <0.001 0.0 0.442 0.235
< 100 1.08 (0.22–5.24) 0.919 69.2 0.071
Mean age (years) ≥ 50.0 1.18 (0.72–1.94) 0.508 63.8 0.063 0.215
< 50.0 0.66 (0.27–1.62) 0.365
Not reported 1.48 (1.16–1.89) 0.001 0.0 0.756
Treatment strategy Surgery alone 1.31 (0.93–1.84) 0.127 0.0 0.797 0.794
Other 1.28 (0.92–1.78) 0.144 49.9 0.076
Cutoff value ≥ 300 1.42 (1.12–1.80) 0.004 19.8 0.284 0.228
< 300 1.02 (0.63–1.65) 0.936 23.6 0.253
Not reported 2.72 (0.61–12.10) 0.189
Adjusted Yes 1.45 (1.11–1.88) 0.006 0.0 0.547 0.539
No 1.23 (0.86–1.75) 0.266 43.9 0.113
Study quality High 1.52 (1.24–1.88) <0.001 0.0 0.789 0.046
Low 0.96 (0.57–1.60) 0.867 37.8 0.185
RFS Publication year Before 2010 8.50 (0.78–92.40) 0.079 0.173
2010 or after 1.60 (1.22–2.10) 0.001 0.7 0.388
Country Eastern 1.71 (1.24–2.34) 0.001 0.0 0.587 0.624
Western 1.98 (0.75–5.24) 0.167 53.9 0.114
Sample size ≥ 100 1.55 (1.17–2.04) 0.002 0.0 0.369 0.140
< 100 3.35 (1.25–9.00) 0.017 0.0 0.400
Mean age (years) < 50.0 1.51 (1.04–2.18) 0.029 17.7 0.297 0.308
Not reported 2.52 (0.82–7.71) 0.105 29.0 0.235
Treatment strategy Surgery alone 1.75 (1.28–2.40) <0.001 0.3 0.367 0.399
Other 1.54 (0.64–3.73) 0.334 53.7 0.141
Cutoff value ≥ 300 2.52 (0.82–7.71) 0.105 29.0 0.235 0.308
< 300 1.51 (1.04–2.18) 0.029 17.7 0.297
Adjusted Yes 2.40 (0.59–9.69) 0.221 45.3 0.176 0.872
No 1.63 (1.00–2.66) 0.048 33.8 0.221
Study quality High 1.60 (1.09–2.36) 0.017 0.886
Low 1.78 (1.04–3.05) 0.034 38.2 0.183